Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

Nancy M. Lee, Leonid Leybin, Jaw Kang Chang, Horace H. Loh

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Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.

Original languageEnglish (US)
Pages (from-to)181-185
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number2
StatePublished - 1980

Bibliographical note

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  • Analgesia
  • FK33824
  • Leu-enkephalin
  • Met-enkephalin
  • Morphine


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