Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

Nancy M. Lee; Leonid Leybin; Jaw Kang Chang; Horace H. Loh

doi:10.1016/0014-2999(80)90319-2

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

Nancy M. Lee, Leonid Leybin, Jaw Kang Chang, Horace H. Loh

Pharmacology

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.

Original language	English (US)
Pages (from-to)	181-185
Number of pages	5
Journal	European Journal of Pharmacology
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(80)90319-2
State	Published - 1980

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Keywords

Analgesia
FK33824
Leu-enkephalin
Met-enkephalin
Morphine

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10.1016/0014-2999(80)90319-2

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abstract = "Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.",

keywords = "Analgesia, FK33824, Leu-enkephalin, Met-enkephalin, Morphine",

author = "Lee, {Nancy M.} and Leonid Leybin and Chang, {Jaw Kang} and Loh, {Horace H.}",

year = "1980",

doi = "10.1016/0014-2999(80)90319-2",

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TY - JOUR

T1 - Opiate and peptide interaction

T2 - Effect of enkephalins on morphine analgesia

AU - Lee, Nancy M.

AU - Leybin, Leonid

AU - Chang, Jaw Kang

AU - Loh, Horace H.

PY - 1980

Y1 - 1980

N2 - Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.

AB - Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.

KW - Analgesia

KW - FK33824

KW - Leu-enkephalin

KW - Met-enkephalin

KW - Morphine

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EP - 185

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

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ER -

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

Abstract

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