Abstract
Interactions between the weakly analgesic enkephalins and morphine on morphine-induced analgesia were studied. Met-enkephalin exhibited morphine analgesia whereas Leu-enkephalin potentiated it. Both Met- and Leu-enkephalin, when tested alone, were not analgesic. The strongly analgesic FK33824 (Sandoz) compound, like Leu-enkephalin, also potentiated morphine analgesia. Tolerance developed to morphine analgesia but not to Met-enkephalin inhibition of morphine analgesia.
Original language | English (US) |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 68 |
Issue number | 2 |
DOIs | |
State | Published - 1980 |
Bibliographical note
Copyright:Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Analgesia
- FK33824
- Leu-enkephalin
- Met-enkephalin
- Morphine