Open fixed dose trial of fluoxetine in the treatment of obsessive compulsive disorder

Suck Won Kim, Maurice W. Dysken

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Twelve non‐depressed DSM‐III obsessive compulsive disorder (OCD) patients were treated with fluoxetine in a 12 week open fixed dose study. After a 2 week washout period, patients were treated with 20 mg/day of fluoxetine for 1 week. The dosage was then raised to 40 mg/day for the remainder of the study. The Yale‐Brown Obsessive Compulsive Scale (Y‐BOCS) score (mean ± SD) decreased from 25.8 ± 4.5 to 15.4 ± 7.0 (P < 0.01) and the Symptom Check List‐90‐Obsessive Compulsive Subscale (SCL‐90‐OC) score (mean ± SD) also showed a decrease from 2.4 ± 0.8 to 1.3 ± 0.9 (P < 0.005). The results suggest that fluoxetine is effective in non‐depressed OCD patients. Our results also show that a 40 mg/day dosage is effective in contrast to previous studies that used 80 mg/day. Our finding of a significant treatment reduction in the SCL‐90‐OC is also in contrast to a previous OCD study in which the SCL‐58‐OC was not significantly reduced.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalDrug Development Research
Volume19
Issue number3
DOIs
StatePublished - 1990

Keywords

  • Leyton Obsessive Compulsive Inventory (LOI)
  • Symptom Check List‐90‐Obsessive Compulsive Subscale (SCL‐90‐OC)
  • Yale‐Brown Obsessive Compulsive Disorder (Y‐BOCS)

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