Ontogeny of normal human B-cell and T-cell precursors and its relation to leukemogenesis

Tucker W LeBien, J. G. Villablanca

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The concept that a pluripotent stem cell exists and has the capacity eventually to give rise to mature B and T cells is uncontestable. However, the precise development relationship between pluripotent stem cells and the earliest stages of B-cell and T-cell development are still obscure. Patterns of gene expression are being identified that characterize normal B-cell and T-cell precursors, and the regulatory variables that influence self-renewal and differentiation of these cells. These are important studies because childhood lymphoblastic leukemia almost always manifests a cellular phenotype consonant with an immature lymphoid cell. A comprehensive understanding of the etiology of acute lymphoblastic leukemia will likely be hastened by a more thorough understanding of normal lymphopoiesis. This knowledge will complement the large data base that currently characterizes lymphoblastic leukemia in children.

Original languageEnglish (US)
Pages (from-to)835-847
Number of pages13
JournalHematology/Oncology Clinics of North America
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1990

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