On‐line monitoring of hybridoma cell growth using a laser turbidity sensor

Konstantin B. Konstantinov, Rindit Pambayun, Ricaredo Matanguihan, Toshiomi Yoshida, Cheryl M. Perusicn, Wei‐Shou ‐S Hu

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A high‐sensitivity turbidity probe was used for on‐line monitoring of the cell concentration in batch hybridoma cultivation. Good correlation between off‐line cell counts and the linearized sensor signal was found. The quality of the signal was sufficiently high to provide for on‐line estimation of the specific growth rate using an efficient filtering procedure. These positive results suggest that such laser turbidity sensors will facilitate development of systems for on‐line monitoring and control of animal cell cultivations. © 1992 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)1337-1342
Number of pages6
JournalBiotechnology and bioengineering
Volume40
Issue number11
DOIs
StatePublished - Dec 20 1992

Keywords

  • bioprocess control
  • cell concentration monitoring
  • growth rate
  • hybridoma growth
  • turbidity sensor

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