Abstract
Equation Presented 3,5-Disubstituted-and 3,4,5-trisubstituted-2-(2-pyridyl)pyrroles may be synthesized efficiently from the novel condensation of 2-(aminomethyl)-pyridine and 1,3-diones. The cyclization reaction was found to proceed through the intermediacy of a (2-pyridyl)methylimine. A marked dependence of the regioselectivity in the reaction of unsymmetrical diones on the presence of additional aminomethylpyridine suggests that two pathways to the product pyrroles are available.
Original language | English (US) |
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Pages (from-to) | 435-437 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Feb 7 2002 |