Experiments measuring DNA extension in nanochannels are at odds with even the most basic predictions of current scaling arguments for the conformations of confined semiflexible polymers such as DNA. We show that a theory based on a weakly self-avoiding, one-dimensional "telegraph" process collapses experimental data and simulation results onto a single master curve throughout the experimentally relevant region of parameter space and explains the mechanisms at play.
Bibliographical noteFunding Information:
We thank Daniel Ödman for helping us to uncover an error in the simulations of the telegraph model. This work was supported by VR Grant No. 2013-3992 and by the National Institutes of Health (R01-HG006851). D. G. acknowledges the support of a Doctoral Dissertation Fellowship from the University of Minnesota. Computational resources were provided by the Minnesota Supercomputing Institute, and by C3SE and SNIC.
Chuang, H., Reifenberger, J. G., Bhandari, A. B. & Dorfman, K., Data Repository for the University of Minnesota, 2019