Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla

Randy S Daughters, Randall D. Hofbauer, Aaron W. Grossman, Anne Marie Marshall, Eric M. Brown, Boyd K Hartman, Patricia L Faris

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Serotonin 5-HT3 antagonists have been suggested for treatment of several disorders involving altered gastrointestinal (GI) function. CCK also has well documented GI actions on both food intake and vago-vagal reflexes. To evaluate potential interactions, the effect of a 5-HT3 antagonist, ondansetron, on exogenous CCK induced satiety and c-fos activation was determined. Ondansetron reduced both actions of CCK by approximately 50%. The reduction in c-fos was localized to a specific subregion of the dorsal medulla, suggesting that a distinct subpopulation of CCK receptive fibers are modulated by 5-HT3 ligands. Treatments using 5-HT3 antagonists also may affect endogenous CCK functions.

Original languageEnglish (US)
Pages (from-to)1331-1338
Number of pages8
JournalPeptides
Volume22
Issue number8
DOIs
StatePublished - 2001

Keywords

  • 5-HT receptors
  • C-fos proteins
  • Cholecystokinin
  • Food intake
  • Ondansetron
  • Vagus nerves

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