Oncolytic adenoviruses: Strategies for improved targeting and specificity

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13 Scopus citations


Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.

Original languageEnglish (US)
Article number1504
Pages (from-to)1-26
Number of pages26
Issue number6
StatePublished - Jun 2020

Bibliographical note

Funding Information:
The works were partly supported by NIH/NCI awards (R01CA196215, R01CA168448, and R01CA228760).

Funding Information:
Funding: The works were partly supported by NIH/NCI R01CA228760)

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Adenovirus vector
  • Library
  • Oncolytic adenovirus
  • Promoter
  • Screening
  • Targeting


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