Oncolytic adenoviruses: Strategies for improved targeting and specificity

Praveensingh B. Hajeri; Nikita S. Sharma; Masato Yamamoto

doi:10.3390/cancers12061504

Oncolytic adenoviruses: Strategies for improved targeting and specificity

Praveensingh B. Hajeri, Nikita S. Sharma, Masato Yamamoto

Surgery

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.

Original language	English (US)
Article number	1504
Pages (from-to)	1-26
Number of pages	26
Journal	Cancers
Volume	12
Issue number	6
DOIs	https://doi.org/10.3390/cancers12061504
State	Published - Jun 2020

Bibliographical note

Funding Information:
The works were partly supported by NIH/NCI awards (R01CA196215, R01CA168448, and R01CA228760).

Funding Information:
Funding: The works were partly supported by NIH/NCI R01CA228760)

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Adenovirus vector
Library
Oncolytic adenovirus
Promoter
Screening
Targeting

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers12061504

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abstract = "Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.",

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AU - Sharma, Nikita S.

AU - Yamamoto, Masato

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N2 - Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.

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KW - Promoter

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KW - Targeting

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Oncolytic adenoviruses: Strategies for improved targeting and specificity

Abstract

Bibliographical note

Keywords

UN SDGs

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