Oncogenes, growth factors, and signal transduction

Lynn A. Burmeister, Cary N. Mariash

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: In a review of oncogenes, growth factors, and signal transduction (Nov. 16 issue),1 a table categorizing known oncogenes and associated neoplasms erroneously classifies the erb A gene as a cytoplasmic hormone receptor. It has been recognized for many years that the thyroid hormone receptor is nuclear regardless of whether it has hormone bound to it.2,3 In December 1986 two groups simultaneously reported that the c-erbA gene encodes a protein with characteristics of the thyroid hormone receptor.4,5 Each group demonstrated binding of this protein to labeled triiodothyronine in nuclear extracts or isolated nuclei. Further substantiation of.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number18
StatePublished - May 3 1990


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