TY - JOUR
T1 - Oncogenes, growth factors, and signal transduction
AU - Burmeister, Lynn A.
AU - Mariash, Cary N.
PY - 1990/5/3
Y1 - 1990/5/3
N2 - To the Editor: In a review of oncogenes, growth factors, and signal transduction (Nov. 16 issue),1 a table categorizing known oncogenes and associated neoplasms erroneously classifies the erb A gene as a cytoplasmic hormone receptor. It has been recognized for many years that the thyroid hormone receptor is nuclear regardless of whether it has hormone bound to it.2,3 In December 1986 two groups simultaneously reported that the c-erbA gene encodes a protein with characteristics of the thyroid hormone receptor.4,5 Each group demonstrated binding of this protein to labeled triiodothyronine in nuclear extracts or isolated nuclei. Further substantiation of.
AB - To the Editor: In a review of oncogenes, growth factors, and signal transduction (Nov. 16 issue),1 a table categorizing known oncogenes and associated neoplasms erroneously classifies the erb A gene as a cytoplasmic hormone receptor. It has been recognized for many years that the thyroid hormone receptor is nuclear regardless of whether it has hormone bound to it.2,3 In December 1986 two groups simultaneously reported that the c-erbA gene encodes a protein with characteristics of the thyroid hormone receptor.4,5 Each group demonstrated binding of this protein to labeled triiodothyronine in nuclear extracts or isolated nuclei. Further substantiation of.
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U2 - 10.1056/NEJM199005033221819
DO - 10.1056/NEJM199005033221819
M3 - Letter
C2 - 2325729
AN - SCOPUS:0025327295
SN - 0028-4793
VL - 322
SP - 1322
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -