On the role of γ-carboxyglutamic acid in calcium and phospholipid binding

Gary L Nelsestuen, Margaret Broderius, Thomas H. Zytkovicz, James Bryant Howard

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The vitamin K-dependent amino acid, γ-carboxyglutamic acid, is essential for calcium binding by prothrombin and blood clotting factor X. The studies reported here demonstrate that while γ-carboxyglutamic acid-containing peptides will bind calcium, a secondary/tertiary protein structure is also necessary to form the tight calcium binding sites which are required for binding these proteins to phospholipid surfaces.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Jul 8 1975

Bibliographical note

Funding Information:
Acknowledgements This work was supported by Research Grant HL-15728 from the National Institutes of Health.


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