TY - JOUR
T1 - On the role of γ-carboxyglutamic acid in calcium and phospholipid binding
AU - Nelsestuen, Gary L
AU - Broderius, Margaret
AU - Zytkovicz, Thomas H.
AU - Howard, James Bryant
PY - 1975/7/8
Y1 - 1975/7/8
N2 - The vitamin K-dependent amino acid, γ-carboxyglutamic acid, is essential for calcium binding by prothrombin and blood clotting factor X. The studies reported here demonstrate that while γ-carboxyglutamic acid-containing peptides will bind calcium, a secondary/tertiary protein structure is also necessary to form the tight calcium binding sites which are required for binding these proteins to phospholipid surfaces.
AB - The vitamin K-dependent amino acid, γ-carboxyglutamic acid, is essential for calcium binding by prothrombin and blood clotting factor X. The studies reported here demonstrate that while γ-carboxyglutamic acid-containing peptides will bind calcium, a secondary/tertiary protein structure is also necessary to form the tight calcium binding sites which are required for binding these proteins to phospholipid surfaces.
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U2 - 10.1016/S0006-291X(75)80084-2
DO - 10.1016/S0006-291X(75)80084-2
M3 - Article
C2 - 1147986
AN - SCOPUS:0016794671
VL - 65
SP - 233
EP - 240
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -