The vitamin K-dependent amino acid, γ-carboxyglutamic acid, is essential for calcium binding by prothrombin and blood clotting factor X. The studies reported here demonstrate that while γ-carboxyglutamic acid-containing peptides will bind calcium, a secondary/tertiary protein structure is also necessary to form the tight calcium binding sites which are required for binding these proteins to phospholipid surfaces.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jul 8 1975|
Bibliographical noteFunding Information:
Acknowledgements This work was supported by Research Grant HL-15728 from the National Institutes of Health.