On the mechanism of reduced tabletability of granules prepared by roller compaction

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In a recent paper published in this journal, authors were perplexed by their results seemingly conflicting with our earlier findings [Sun, C.C., Himmelspach, M.W., 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J. Pharm. Sci. 95, 200-206]. After carefully reviewing the two studies, we conclude that results in the two studies are actually consistent with each other.

Original languageEnglish (US)
Pages (from-to)171-172
Number of pages2
JournalInternational journal of pharmaceutics
Issue number1-2
StatePublished - Jan 22 2008


  • Dry granulation
  • Granule size
  • Powder compaction
  • Roller compaction
  • Tabletability

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