On the emergence of autism: Neuroimaging findings from birth to preschool

Jason J. Wolff, Joseph Piven

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

By definition, autism spectrum disorder (ASD) emerges early in life. Core clinical symptoms generally appear after a childs first birthday, and most children receive a diagnosis by the age of 4 years. This relatively narrow window of birth to age of onset affords the opportunity to chart the neurodevelopmental processes that give rise to ASD. Although much remains unknown, magnetic resonance brain imaging studies centered around the emergence of the disorder have yielded important clues about its pathogenesis. Prominent findings include evidence of increased cortical gray and white matter volumes, increased amygdala volumes, aberrant structural and functional connectivity, and atypical neurodevelopmental trajectories. Findings to date suggest a disrupted pattern of early brain development during an interval typically characterized by dramatic experience-dependent neurobehavioral development. Developmentally informed neuroimaging studies of ASD have the potential to improve our knowledge pertaining to etiology and early intervention.

Original languageEnglish (US)
Pages (from-to)209-222
Number of pages14
JournalNeuropsychiatry
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2013

Fingerprint

Autistic Disorder
Neuroimaging
Parturition
Amygdala
Age of Onset
Magnetic Resonance Imaging
Brain
Autism Spectrum Disorder

Cite this

On the emergence of autism : Neuroimaging findings from birth to preschool. / Wolff, Jason J.; Piven, Joseph.

In: Neuropsychiatry, Vol. 3, No. 2, 01.04.2013, p. 209-222.

Research output: Contribution to journalReview article

@article{4f6c4b9024724d2eaab224f79586d882,
title = "On the emergence of autism: Neuroimaging findings from birth to preschool",
abstract = "By definition, autism spectrum disorder (ASD) emerges early in life. Core clinical symptoms generally appear after a childs first birthday, and most children receive a diagnosis by the age of 4 years. This relatively narrow window of birth to age of onset affords the opportunity to chart the neurodevelopmental processes that give rise to ASD. Although much remains unknown, magnetic resonance brain imaging studies centered around the emergence of the disorder have yielded important clues about its pathogenesis. Prominent findings include evidence of increased cortical gray and white matter volumes, increased amygdala volumes, aberrant structural and functional connectivity, and atypical neurodevelopmental trajectories. Findings to date suggest a disrupted pattern of early brain development during an interval typically characterized by dramatic experience-dependent neurobehavioral development. Developmentally informed neuroimaging studies of ASD have the potential to improve our knowledge pertaining to etiology and early intervention.",
author = "Wolff, {Jason J.} and Joseph Piven",
year = "2013",
month = "4",
day = "1",
doi = "10.2217/npy.13.11",
language = "English (US)",
volume = "3",
pages = "209--222",
journal = "Neuropsychiatry",
issn = "1758-2008",
publisher = "University of Virginia",
number = "2",

}

TY - JOUR

T1 - On the emergence of autism

T2 - Neuroimaging findings from birth to preschool

AU - Wolff, Jason J.

AU - Piven, Joseph

PY - 2013/4/1

Y1 - 2013/4/1

N2 - By definition, autism spectrum disorder (ASD) emerges early in life. Core clinical symptoms generally appear after a childs first birthday, and most children receive a diagnosis by the age of 4 years. This relatively narrow window of birth to age of onset affords the opportunity to chart the neurodevelopmental processes that give rise to ASD. Although much remains unknown, magnetic resonance brain imaging studies centered around the emergence of the disorder have yielded important clues about its pathogenesis. Prominent findings include evidence of increased cortical gray and white matter volumes, increased amygdala volumes, aberrant structural and functional connectivity, and atypical neurodevelopmental trajectories. Findings to date suggest a disrupted pattern of early brain development during an interval typically characterized by dramatic experience-dependent neurobehavioral development. Developmentally informed neuroimaging studies of ASD have the potential to improve our knowledge pertaining to etiology and early intervention.

AB - By definition, autism spectrum disorder (ASD) emerges early in life. Core clinical symptoms generally appear after a childs first birthday, and most children receive a diagnosis by the age of 4 years. This relatively narrow window of birth to age of onset affords the opportunity to chart the neurodevelopmental processes that give rise to ASD. Although much remains unknown, magnetic resonance brain imaging studies centered around the emergence of the disorder have yielded important clues about its pathogenesis. Prominent findings include evidence of increased cortical gray and white matter volumes, increased amygdala volumes, aberrant structural and functional connectivity, and atypical neurodevelopmental trajectories. Findings to date suggest a disrupted pattern of early brain development during an interval typically characterized by dramatic experience-dependent neurobehavioral development. Developmentally informed neuroimaging studies of ASD have the potential to improve our knowledge pertaining to etiology and early intervention.

UR - http://www.scopus.com/inward/record.url?scp=84876125884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876125884&partnerID=8YFLogxK

U2 - 10.2217/npy.13.11

DO - 10.2217/npy.13.11

M3 - Review article

AN - SCOPUS:84876125884

VL - 3

SP - 209

EP - 222

JO - Neuropsychiatry

JF - Neuropsychiatry

SN - 1758-2008

IS - 2

ER -