On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke

Karam El-bayoumy; Marianne O'donnell; Stephen S. Hecht; Dietrich Hoffmann

doi:10.1093/carcin/6.4.505

On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke

Karam El-bayoumy
, Marianne O'donnell
, Stephen S. Hecht
, Dietrich Hoffmann

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [¹⁴C]1-nitronaphthalene, [¹⁴C]1-nitropyrene, and [¹⁴C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.

Original language	English (US)
Pages (from-to)	505-507
Number of pages	3
Journal	Carcinogenesis
Volume	6
Issue number	4
DOIs	https://doi.org/10.1093/carcin/6.4.505
State	Published - Apr 1985

Bibliographical note

Funding Information:
We thank John D. Adams for continuous help and Mrs. Debbie Conroy for preparing this manuscript. This work was supported by Grant No. PO1-CA-29580 and Grant No. 35519 from the National Cancer Institute. This is No. LXXXII of Chemical Studies on Tobacco Smoke.

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@article{2e91d2bb4d7341f4886a884077b5f8ce,

title = "On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke",

abstract = "A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [14C]1-nitronaphthalene, [14C]1-nitropyrene, and [14C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70\%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.",

author = "Karam El-bayoumy and Marianne O'donnell and Hecht, \{Stephen S.\} and Dietrich Hoffmann",

note = "Funding Information: We thank John D. Adams for continuous help and Mrs. Debbie Conroy for preparing this manuscript. This work was supported by Grant No. PO1-CA-29580 and Grant No. 35519 from the National Cancer Institute. This is No. LXXXII of Chemical Studies on Tobacco Smoke.",

year = "1985",

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doi = "10.1093/carcin/6.4.505",

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T1 - On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke

AU - El-bayoumy, Karam

AU - O'donnell, Marianne

AU - Hecht, Stephen S.

AU - Hoffmann, Dietrich

N1 - Funding Information: We thank John D. Adams for continuous help and Mrs. Debbie Conroy for preparing this manuscript. This work was supported by Grant No. PO1-CA-29580 and Grant No. 35519 from the National Cancer Institute. This is No. LXXXII of Chemical Studies on Tobacco Smoke.

PY - 1985/4

Y1 - 1985/4

N2 - A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [14C]1-nitronaphthalene, [14C]1-nitropyrene, and [14C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.

AB - A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [14C]1-nitronaphthalene, [14C]1-nitropyrene, and [14C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.

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DO - 10.1093/carcin/6.4.505

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AN - SCOPUS:0021950020

SN - 0143-3334

VL - 6

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JO - Carcinogenesis

JF - Carcinogenesis

IS - 4

ER -

On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke

Abstract

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