On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke

Karam El-bayoumy, Marianne O'donnell, Stephen S. Hecht, Dietrich Hoffmann

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20 Scopus citations

Abstract

A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [14C]1-nitronaphthalene, [14C]1-nitropyrene, and [14C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalCarcinogenesis
Volume6
Issue number4
DOIs
StatePublished - Apr 1985

Bibliographical note

Funding Information:
We thank John D. Adams for continuous help and Mrs. Debbie Conroy for preparing this manuscript. This work was supported by Grant No. PO1-CA-29580 and Grant No. 35519 from the National Cancer Institute. This is No. LXXXII of Chemical Studies on Tobacco Smoke.

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