Abstract
A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [14C]1-nitronaphthalene, [14C]1-nitropyrene, and [14C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 505-507 |
| Number of pages | 3 |
| Journal | Carcinogenesis |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1985 |
Bibliographical note
Funding Information:We thank John D. Adams for continuous help and Mrs. Debbie Conroy for preparing this manuscript. This work was supported by Grant No. PO1-CA-29580 and Grant No. 35519 from the National Cancer Institute. This is No. LXXXII of Chemical Studies on Tobacco Smoke.