On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke

Karam El-bayoumy, Marianne O'donnell, Stephen S. Hecht, Dietrich Hoffmann

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


A method was developed for the analysis of 1-nitro-naphthalene, 1-nitropyrene, and 6-nitrochrysene in main stream cigarette smoke, using [14C]1-nitronaphthalene, [14C]1-nitropyrene, and [14C]6-nitrochrysene as tracers and internal standards. Cigarette smoke condensate was collected and the appropriate fractions containing the labelled standards were obtained by a series of solvent partitions and column chromatography. Recovery of internal standards ranged from 60 to 70%. The fractions were analyzed by capillary gas chromatography with electron capture detection and by combined capillary gas chromatography - mass spectrometry. 1-Nitronaphthalene (<10ng/cigarette), 1-ni-tropyrene (<10ng/cigarette), and 6-nitrochrysene (<1ng/cigarette) were not detected in the mainstream smoke of the University of Kentucky 1R1 cigarette, a US commercial 85 mm non-filter cigarette, or a French commercial 70 mm non-filter cigarette.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
Issue number4
StatePublished - Apr 1985

Bibliographical note

Funding Information:
We thank John D. Adams for continuous help and Mrs. Debbie Conroy for preparing this manuscript. This work was supported by Grant No. PO1-CA-29580 and Grant No. 35519 from the National Cancer Institute. This is No. LXXXII of Chemical Studies on Tobacco Smoke.

Fingerprint Dive into the research topics of 'On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke'. Together they form a unique fingerprint.

Cite this