On recent advances in synthetic biology to enable programming bacteria for biosensing applications

Meghdad Hajimorad; Jeffrey A. Gralnick

doi:10.1109/MWSCAS.2017.8053193

On recent advances in synthetic biology to enable programming bacteria for biosensing applications

Meghdad Hajimorad, Jeffrey A. Gralnick

Biotechnology Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The genetic engineering of microbial organisms offers benefits to society through biotechnology applications. Traditionally, the 'engineering' of microbes to arrive at organisms with desired behavior has not been engineering in a strict sense. It has, rather, required months (more often years) of trial-and-error type of experiments, with the undertaking being more akin to art than engineering. Enter synthetic biology, a burgeoning area since the turn of the century that aims to put the engineering into genetic engineering. Here, we provide a short commentary on some advancements in this field. By relating these advances to recent progress in our understanding of extracellular electron transfer in bacteria, we also provide a perspective on synthetic biology having the potential to enable the programming of bacteria for electronics engineering-related applications such as biosensors.

Original language	English (US)
Title of host publication	2017 IEEE 60th International Midwest Symposium on Circuits and Systems, MWSCAS 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1398-1401
Number of pages	4
ISBN (Electronic)	9781509063895
DOIs	https://doi.org/10.1109/MWSCAS.2017.8053193
State	Published - Sep 27 2017
Event	60th IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2017 - Boston, United States Duration: Aug 6 2017 → Aug 9 2017

Publication series

Name	Midwest Symposium on Circuits and Systems
Volume	2017-August
ISSN (Print)	1548-3746

Other

Other	60th IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2017
Country/Territory	United States
City	Boston
Period	8/6/17 → 8/9/17

Bibliographical note

Funding Information:
ACKNOWLEDGMENT This work was supported, in part, by the Office of Naval Research (N00014-13-1-0552 to JAG). The authors acknowledge Michael Winikoff, Communications Director at the BioTechnology Institute of the University of Minnesota – Twin Cities, for creating Fig. 3.

Publisher Copyright:
© 2017 IEEE.

Publisher link

10.1109/MWSCAS.2017.8053193

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Hajimorad, M., & Gralnick, J. A. (2017). On recent advances in synthetic biology to enable programming bacteria for biosensing applications. In 2017 IEEE 60th International Midwest Symposium on Circuits and Systems, MWSCAS 2017 (pp. 1398-1401). Article 8053193 (Midwest Symposium on Circuits and Systems; Vol. 2017-August). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MWSCAS.2017.8053193

On recent advances in synthetic biology to enable programming bacteria for biosensing applications. / Hajimorad, Meghdad; Gralnick, Jeffrey A.
2017 IEEE 60th International Midwest Symposium on Circuits and Systems, MWSCAS 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1398-1401 8053193 (Midwest Symposium on Circuits and Systems; Vol. 2017-August).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hajimorad, M & Gralnick, JA 2017, On recent advances in synthetic biology to enable programming bacteria for biosensing applications. in 2017 IEEE 60th International Midwest Symposium on Circuits and Systems, MWSCAS 2017., 8053193, Midwest Symposium on Circuits and Systems, vol. 2017-August, Institute of Electrical and Electronics Engineers Inc., pp. 1398-1401, 60th IEEE International Midwest Symposium on Circuits and Systems, MWSCAS 2017, Boston, United States, 8/6/17. https://doi.org/10.1109/MWSCAS.2017.8053193

Hajimorad M, Gralnick JA. On recent advances in synthetic biology to enable programming bacteria for biosensing applications. In 2017 IEEE 60th International Midwest Symposium on Circuits and Systems, MWSCAS 2017. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1398-1401. 8053193. (Midwest Symposium on Circuits and Systems). doi: 10.1109/MWSCAS.2017.8053193

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abstract = "The genetic engineering of microbial organisms offers benefits to society through biotechnology applications. Traditionally, the 'engineering' of microbes to arrive at organisms with desired behavior has not been engineering in a strict sense. It has, rather, required months (more often years) of trial-and-error type of experiments, with the undertaking being more akin to art than engineering. Enter synthetic biology, a burgeoning area since the turn of the century that aims to put the engineering into genetic engineering. Here, we provide a short commentary on some advancements in this field. By relating these advances to recent progress in our understanding of extracellular electron transfer in bacteria, we also provide a perspective on synthetic biology having the potential to enable the programming of bacteria for electronics engineering-related applications such as biosensors.",

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On recent advances in synthetic biology to enable programming bacteria for biosensing applications

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