On-chip electrochemical detection of bio/chemical molecule by nanostructures fabricated in a microfluidic channel

Kwi Nam Han, Cheng Ai Li, Minh Phuong Ngoc Bui, Xuan Hung Pham, Bum Sung Kim, Yong Ho Choa, Eun Kyu Lee, Gi Hun Seong

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


We developed the versatile microfluidic device for on-chip electrochemical analysis in a single integrated platform. Gold nanostructures were fabricated at defined positions within microchannels by electrochemical deposition, and used as electrocatalytic materials for glucose detection and suitable sensing surfaces for ultratrace arsenic(III) detection. The continuous streaming solution in microfluidic devices allowed for enhanced mass transport to the electrodes and elimination of fouling effects, resulting in increased currents and high sensitivities. As a result, the current response showed a strong linear dependence (R2 = 0.995) in the glucose concentration range of 0.1-9 mM with an excellent sensitivity of 1.10 ± 0.07 mA cm-2 mM-1. Furthermore, in ultratrace arsenic(III) analysis, the calibration plot corresponding to peak current shows good linearity (R 2 = 0.998) up to the concentration of 30 ppb and remarkable sensitivity of 4.49 ± 1.01 μA cm-2 ppb-1 in a short accumulation time of 60 s. We believe that the proposed device is a promising approach for various microfluidic applications with the extensibility of functional nanostructures and possibility of biomolecule self-assembly.

Original languageEnglish (US)
Pages (from-to)472-477
Number of pages6
JournalSensors and Actuators, B: Chemical
StatePublished - 2013
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by National Research Foundation (NRF) grants funded by the Korean government (MEST) (No. 2012-0005314 , No. 2011-0026266 , and No. 2008-0061857 ). We also acknowledge the financial support of the Ministry of Knowledge Economy (MKE) through the industrial infrastructure program for fundamental technologies (N000600001).


  • Electrochemical detection
  • Gold nanoparticles
  • Microfluidic device
  • Single-walled carbon nanotube


Dive into the research topics of 'On-chip electrochemical detection of bio/chemical molecule by nanostructures fabricated in a microfluidic channel'. Together they form a unique fingerprint.

Cite this