On-beam synchrony in the cerebellum as the mechanism for the timing and coordination of movement

D. H. Heck, W. T. Thach, J. G. Keating

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

In trained reaching rats, we recorded simple spikes of pairs of Purkinje cells that, with respect to each other, were either aligned on a beam of shared parallel fibers or instead were located off beam. Rates of simple spike firing in both on-beam and off-beam Purkinje cell pairs commonly showed great variety in depth of modulation during reaching behavior. But with respect to timing, on-beam Purkinje cell pairs had simple spikes that were tightly time-locked to each other (either delayed or simultaneous) and to movement, despite the variability in rate. By contrast, off-beam Purkinje cell pairs had simple spikes that were not time-locked to each other, neither delayed nor simultaneous. We discuss the implications of these observations for the cerebellar role in timing and coordinating movement.

Original languageEnglish (US)
Pages (from-to)7658-7663
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number18
DOIs
StatePublished - May 1 2007
Externally publishedYes

Keywords

  • Awake reaching rat
  • Parallel fibers
  • Purkinje cell
  • Simple spike

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