On 3-D graphical representation of DNA primary sequences and their numerical characterization

M. Randić, M. Vračko, A. Nandy, Subhash C Basak

Research output: Contribution to journalArticlepeer-review

297 Scopus citations

Abstract

In this article we (1) outline the construction of a 3-D "graphical" representation of DNA primary sequences, illustrated on a portion of the human β globin gene; (2) describe a particular scheme that transforms the above 3-D spatial representation of DNA into a numerical matrix representation; (3) illustrate construction of matrix invariants for DNA sequences; and (4) suggest a data reduction based on statistical analysis of matrix invariants generated for DNA. Each of the four contributions represents a novel development that we hope will facilitate comparative studies of DNA and open new directions for representation and characterization of DNA primary sequences.

Original languageEnglish (US)
Pages (from-to)1235-1244
Number of pages10
JournalJournal of chemical information and computer sciences
Volume40
Issue number5
DOIs
StatePublished - Jan 1 2000

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