OMCD

OncomiR Cancer Database

Aaron L Sarver, Anne E Sarver, Angelo Yuan, Subree Subramanian

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: microRNAs (miRNAs) are crucially important in the development of cancer. Their dysregulation, commonly observed in various types of cancer, is largely cancer-dependent. Thus, to understand the tumor biology and to develop accurate and sensitive biomarkers, we need to understand pan-cancer miRNA expression. Constructions: At the University of Minnesota, we developed the OncomiR Cancer Database (OMCD), hosted on a web server, which allows easy and systematic comparative genomic analyses of miRNA sequencing data derived from more than 9500 cancer patients tissue samples available in the Cancer Genome Atlas (TCGA). OMCD includes associated clinical information and is searchable by organ-specific terms common to the TCGA. Conclusions: Freely available to all users (www.oncomir.umn.edu/omcd/), OMCD enables (1) simple visualization of TCGA miRNA sequencing data, (2) statistical analysis of differentially expressed miRNAs for each cancer type, and (3) exploration of miRNA clusters across cancer types.

Original languageEnglish (US)
Article number5085
JournalBMC Cancer
Volume18
Issue number1
DOIs
StatePublished - Dec 6 2018

Fingerprint

Databases
MicroRNAs
Neoplasms
Atlases
Genome
Statistical Data Interpretation
Biomarkers

Keywords

  • Cancer
  • Database
  • OncomiR
  • TCGA
  • miRNA
  • miRNA expression profile
  • microRNA

PubMed: MeSH publication types

  • Journal Article

Cite this

OMCD : OncomiR Cancer Database. / Sarver, Aaron L; Sarver, Anne E; Yuan, Angelo; Subramanian, Subree.

In: BMC Cancer, Vol. 18, No. 1, 5085, 06.12.2018.

Research output: Contribution to journalArticle

Sarver, Aaron L ; Sarver, Anne E ; Yuan, Angelo ; Subramanian, Subree. / OMCD : OncomiR Cancer Database. In: BMC Cancer. 2018 ; Vol. 18, No. 1.
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