Abstract
Two cases of high-grade glioma comprising sheets of oligodendroglial cells multifocally disrupted by regions of remarkable neuronal differentiation are described. These tumours morphologically resemble ‘oligodendroglioma with ganglioglioma-like maturation’, a rare tumour of man, but appear to be phenotypically more aggressive. Neuronal markers (synaptophysin, neuron-specific enolase and βIII-tubulin) effectively highlight neuronal elements within these tumours and could potentially help to further investigate the prevalence and biological significance of neuronal differentiation in canine oligodendroglioma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-16 |
| Number of pages | 6 |
| Journal | Journal of Comparative Pathology |
| Volume | 172 |
| DOIs | |
| State | Published - Oct 2019 |
Bibliographical note
Funding Information:We thank P. Overn and K. Kovacs in the Comparative Pathology Shared Resource for technical assistance. The present address of the first author is: Janssen R&D, San Diego, California 92121, USA.
Funding Information:
The authors declare no potential conflicts of interest with respect to the research, authorship and/or publication of this article. This work was supported by a grant from Humor to Fight the Tumor, a non-profit organization.
Publisher Copyright:
© 2019 Elsevier Ltd
Keywords
- dog
- glioma
- neuronal differentiation
- oligodendroglioma
