Oligodendroglioma with Neuronal Differentiation in Two Boxer Dogs

I. Cornax, G. E. Pluhar, H. B. Clark, M. G. O'Sullivan

Research output: Contribution to journalArticlepeer-review


Two cases of high-grade glioma comprising sheets of oligodendroglial cells multifocally disrupted by regions of remarkable neuronal differentiation are described. These tumours morphologically resemble ‘oligodendroglioma with ganglioglioma-like maturation’, a rare tumour of man, but appear to be phenotypically more aggressive. Neuronal markers (synaptophysin, neuron-specific enolase and βIII-tubulin) effectively highlight neuronal elements within these tumours and could potentially help to further investigate the prevalence and biological significance of neuronal differentiation in canine oligodendroglioma.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalJournal of Comparative Pathology
StatePublished - Oct 2019

Bibliographical note

Funding Information:
The authors declare no potential conflicts of interest with respect to the research, authorship and/or publication of this article. This work was supported by a grant from Humor to Fight the Tumor, a non-profit organization.


  • dog
  • glioma
  • neuronal differentiation
  • oligodendroglioma

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