Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

Tommaso Cassano, Adele Romano, Teresa Macheda, Roberto Colangeli, Concetta Stefania Cimmino, Antonio Petrella, Frank M. LaFerla, Vincenzo Cuomo, Silvana Gaetani

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43 Scopus citations


Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3× Tg-AD). In the social transmission of food preference test, 3× Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aβ and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.

Original languageEnglish (US)
Pages (from-to)408-412
Number of pages5
JournalBehavioural Brain Research
Issue number2
StatePublished - Oct 31 2011

Bibliographical note

Copyright 2012 Elsevier B.V., All rights reserved.


  • Alzheimer's disease
  • Olfactory circuitry
  • Olfactory memory
  • Social transmission of food preference
  • Triple transgenic model of AD


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