Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

Tommaso Cassano; Adele Romano; Teresa Macheda; Roberto Colangeli; Concetta Stefania Cimmino; Antonio Petrella; Frank M. LaFerla; Vincenzo Cuomo; Silvana Gaetani

doi:10.1016/j.bbr.2011.06.029

Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

Tommaso Cassano, Adele Romano, Teresa Macheda, Roberto Colangeli, Concetta Stefania Cimmino, Antonio Petrella, Frank M. LaFerla, Vincenzo Cuomo, Silvana Gaetani

Medical School - Twin Cities Campus

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Abstract

Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3× Tg-AD). In the social transmission of food preference test, 3× Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aβ and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.

Original language	English (US)
Pages (from-to)	408-412
Number of pages	5
Journal	Behavioural Brain Research
Volume	224
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2011.06.029
State	Published - Oct 31 2011

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Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

Alzheimer's disease
Olfactory circuitry
Olfactory memory
Social transmission of food preference
Triple transgenic model of AD

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10.1016/j.bbr.2011.06.029

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title = "Olfactory memory is impaired in a triple transgenic model of Alzheimer disease",

abstract = "Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3× Tg-AD). In the social transmission of food preference test, 3× Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aβ and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.",

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AU - Cassano, Tommaso

AU - Romano, Adele

AU - Macheda, Teresa

AU - Colangeli, Roberto

AU - Cimmino, Concetta Stefania

AU - Petrella, Antonio

AU - LaFerla, Frank M.

AU - Cuomo, Vincenzo

AU - Gaetani, Silvana

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AB - Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3× Tg-AD). In the social transmission of food preference test, 3× Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aβ and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.

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Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

Abstract

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