TY - JOUR
T1 - Olanzapine for the treatment of borderline personality disorder
T2 - Variable dose 12-week randomised double-blind placebo-controlled study
AU - Schulz, S. Charles
AU - Zanarini, Mary C.
AU - Bateman, Anthony
AU - Bohus, Martin
AU - Detke, Holland C.
AU - Trzaskoma, Quynh
AU - Tanaka, Yoko
AU - Lin, Daniel
AU - Deberdt, Walter
AU - Corya, Sara
PY - 2008/12
Y1 - 2008/12
N2 - Background: Despite the prevalence and clinical significance of borderline personality disorder, its treatment remains understudied. Aims: To evaluate treatment with variably dosed olanzapine in individuals with borderline personality disorder. Method: In this 12-week randomised, double-blind trial, individuals received olanzapine (2.5-20 mg/day; n=155) or placebo (n=159) (trial registry: NCT00091650). The primary efficacy measure was baseline to end-point change on the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) using last-observation-carried-forward methodology. Results: Both olanzapine and placebo groups showed significant improvements but did not differ in magnitude at end-point (-6.56 v. -6.25, P=0.661). Response rates (50% reduction in ZAN-BPD) were 64.7% with olanzapine and 53.5% with placebo (P=0.062); however, time to response was significantly shorter for olanzapine (P=0.022). weight gain was significantly greater (2.86 v. -0.35kg, P < 0.001), with higher incidence of treatment-emergent abnormal high levels of prolactin for the olanzapine group. Conclusions: Individuals treated with olanzapine and placebo showed significant but not statistically different improvements on overall symptoms of borderline personality disorder. The types of adverse events observed with olanzapine treatment appeared similar to those observed previously in adult populations.
AB - Background: Despite the prevalence and clinical significance of borderline personality disorder, its treatment remains understudied. Aims: To evaluate treatment with variably dosed olanzapine in individuals with borderline personality disorder. Method: In this 12-week randomised, double-blind trial, individuals received olanzapine (2.5-20 mg/day; n=155) or placebo (n=159) (trial registry: NCT00091650). The primary efficacy measure was baseline to end-point change on the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) using last-observation-carried-forward methodology. Results: Both olanzapine and placebo groups showed significant improvements but did not differ in magnitude at end-point (-6.56 v. -6.25, P=0.661). Response rates (50% reduction in ZAN-BPD) were 64.7% with olanzapine and 53.5% with placebo (P=0.062); however, time to response was significantly shorter for olanzapine (P=0.022). weight gain was significantly greater (2.86 v. -0.35kg, P < 0.001), with higher incidence of treatment-emergent abnormal high levels of prolactin for the olanzapine group. Conclusions: Individuals treated with olanzapine and placebo showed significant but not statistically different improvements on overall symptoms of borderline personality disorder. The types of adverse events observed with olanzapine treatment appeared similar to those observed previously in adult populations.
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U2 - 10.1192/bjp.bp.107.037903
DO - 10.1192/bjp.bp.107.037903
M3 - Article
C2 - 19043153
AN - SCOPUS:57449115534
SN - 0007-1250
VL - 193
SP - 485
EP - 492
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 6
ER -