TY - JOUR
T1 - Of mice, dirty mice, and men
T2 - Using mice to understand human immunology
AU - Masopust, David
AU - Sivula, Christine P.
AU - Jameson, Stephen C.
N1 - Publisher Copyright:
© 2017 by The American Association of Immunologists, Inc.
PY - 2017/7/15
Y1 - 2017/7/15
N2 - Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.
AB - Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.
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UR - http://www.scopus.com/inward/citedby.url?scp=85023204134&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1700453
DO - 10.4049/jimmunol.1700453
M3 - Review article
C2 - 28696328
AN - SCOPUS:85023204134
SN - 0022-1767
VL - 199
SP - 383
EP - 388
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -