Of mice, dirty mice, and men: Using mice to understand human immunology

David Masopust; Christine P. Sivula; Stephen C. Jameson

doi:10.4049/jimmunol.1700453

Of mice, dirty mice, and men: Using mice to understand human immunology

David Masopust, Christine P. Sivula, Stephen C. Jameson

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.

Original language	English (US)
Pages (from-to)	383-388
Number of pages	6
Journal	Journal of Immunology
Volume	199
Issue number	2
DOIs	https://doi.org/10.4049/jimmunol.1700453
State	Published - Jul 15 2017

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grants R01AI084913 (to D.M.) and R01AI116678 (to S.J.C.).

Publisher Copyright:
© 2017 by The American Association of Immunologists, Inc.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Access

10.4049/jimmunol.1700453

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512602

Fingerprint Dive into the research topics of 'Of mice, dirty mice, and men: Using mice to understand human immunology'. Together they form a unique fingerprint.

Cite this

@article{528a79c0fd854c569e7387cf11cb7be2,

title = "Of mice, dirty mice, and men: Using mice to understand human immunology",

abstract = "Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a {"}dirty{"} mouse model that better mimics the diverse infectious history that is typical of most humans.",

author = "David Masopust and Sivula, {Christine P.} and Jameson, {Stephen C.}",

note = "Funding Information: This work was supported by National Institutes of Health Grants R01AI084913 (to D.M.) and R01AI116678 (to S.J.C.). Publisher Copyright: {\textcopyright} 2017 by The American Association of Immunologists, Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = jul,

day = "15",

doi = "10.4049/jimmunol.1700453",

language = "English (US)",

volume = "199",

pages = "383--388",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "2",

}

TY - JOUR

T1 - Of mice, dirty mice, and men

T2 - Using mice to understand human immunology

AU - Masopust, David

AU - Sivula, Christine P.

AU - Jameson, Stephen C.

N1 - Funding Information: This work was supported by National Institutes of Health Grants R01AI084913 (to D.M.) and R01AI116678 (to S.J.C.). Publisher Copyright: © 2017 by The American Association of Immunologists, Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/7/15

Y1 - 2017/7/15

N2 - Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.

AB - Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.

UR - http://www.scopus.com/inward/record.url?scp=85023204134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023204134&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.1700453

DO - 10.4049/jimmunol.1700453

M3 - Review article

C2 - 28696328

AN - SCOPUS:85023204134

VL - 199

SP - 383

EP - 388

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 2

ER -

Of mice, dirty mice, and men: Using mice to understand human immunology

Abstract

Bibliographical note

Access

Other files and links

Cite this