TY - JOUR
T1 - Ocular permeability after systemic administration of endotoxin in humans
AU - Herman, David C
AU - Suffredini, Anthony F.
AU - Parrillo, Joseph E.
AU - Palestine, Alan G.
PY - 1991
Y1 - 1991
N2 - Acute anterior uveitis in response to the administration of systemic gram-negative endotoxin was studied in humans. The blood-aqueous barrier was evaluated in eight normal human subjects at 8 or 24 hours after systemic administration of purified gram-negative endotoxin. No significant changes in the blood-aqueous barrier were found, as evaluated by permeability to fluorescein, number of aqueous cells, flare, or intraocular pressure, despite profound endotoxin-induced cardiac, pulmonary, and circulatory effects. Gram-negative endotoxin does not appear to affect the human blood-aqueous barrier in doses that can safely be given to humans.
AB - Acute anterior uveitis in response to the administration of systemic gram-negative endotoxin was studied in humans. The blood-aqueous barrier was evaluated in eight normal human subjects at 8 or 24 hours after systemic administration of purified gram-negative endotoxin. No significant changes in the blood-aqueous barrier were found, as evaluated by permeability to fluorescein, number of aqueous cells, flare, or intraocular pressure, despite profound endotoxin-induced cardiac, pulmonary, and circulatory effects. Gram-negative endotoxin does not appear to affect the human blood-aqueous barrier in doses that can safely be given to humans.
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U2 - 10.3109/02713689109001739
DO - 10.3109/02713689109001739
M3 - Article
C2 - 2036803
AN - SCOPUS:0025980910
SN - 0271-3683
VL - 10
SP - 121
EP - 126
JO - Current Eye Research
JF - Current Eye Research
IS - 2
ER -