Ocular permeability after systemic administration of endotoxin in humans

David C Herman, Anthony F. Suffredini, Joseph E. Parrillo, Alan G. Palestine

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Acute anterior uveitis in response to the administration of systemic gram-negative endotoxin was studied in humans. The blood-aqueous barrier was evaluated in eight normal human subjects at 8 or 24 hours after systemic administration of purified gram-negative endotoxin. No significant changes in the blood-aqueous barrier were found, as evaluated by permeability to fluorescein, number of aqueous cells, flare, or intraocular pressure, despite profound endotoxin-induced cardiac, pulmonary, and circulatory effects. Gram-negative endotoxin does not appear to affect the human blood-aqueous barrier in doses that can safely be given to humans.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalCurrent Eye Research
Volume10
Issue number2
DOIs
StatePublished - 1991

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