Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity

Gerard Sabenya, Ilaria Gamba, Laura Gómez, Martin Clémancey, Jonathan R. Frisch, Eric J. Klinker, Geneviève Blondin, Stéphane Torelli, Lawrence Que, Vlad Martin-Diaconescu, Jean Marc Latour, Julio Lloret-Fillol, Miquel Costas

Research output: Contribution to journalArticle

Abstract

High valent iron species are very reactive molecules involved in oxidation reactions of relevance to biology and chemical synthesis. Herein we describe iron(iv)-tosylimido complexes [FeIV(NTs)(MePy2tacn)](OTf)2 (1(IV)NTs) and [FeIV(NTs)(Me2(CHPy2)tacn)](OTf)2 (2(IV)NTs), (MePy2tacn = N-methyl-N,N-bis(2-picolyl)-1,4,7-triazacyclononane, and Me2(CHPy2)tacn = 1-(di(2-pyridyl)methyl)-4,7-dimethyl-1,4,7-triazacyclononane, Ts = Tosyl). 1(IV)NTs and 2(IV)NTs are rare examples of octahedral iron(iv)-imido complexes and are isoelectronic analogues of the recently described iron(iv)-oxo complexes [FeIV(O)(L)]2+ (L = MePy2tacn and Me2(CHPy2)tacn, respectively). 1(IV)NTs and 2(IV)NTs are metastable and have been spectroscopically characterized by HR-MS, UV-vis, 1H-NMR, resonance Raman, Mössbauer, and X-ray absorption (XAS) spectroscopy as well as by DFT computational methods. Ferric complexes [FeIII(HNTs)(L)]2+, 1(III)-NHTs (L = MePy2tacn) and 2(III)-NHTs (L = Me2(CHPy2)tacn) have been isolated after the decay of 1(IV)NTs and 2(IV)NTs in solution, spectroscopically characterized, and the molecular structure of [FeIII(HNTs)(MePy2tacn)](SbF6)2 determined by single crystal X-ray diffraction. Reaction of 1(IV)NTs and 2(IV)NTs with different p-substituted thioanisoles results in the transfer of the tosylimido moiety to the sulphur atom producing sulfilimine products. In these reactions, 1(IV)NTs and 2(IV)NTs behave as single electron oxidants and Hammett analyses of reaction rates evidence that tosylimido transfer is more sensitive than oxo transfer to charge effects. In addition, reaction of 1(IV)NTs and 2(IV)NTs with hydrocarbons containing weak C-H bonds results in the formation of 1(III)-NHTs and 2(III)-NHTs respectively, along with the oxidized substrate. Kinetic analyses indicate that reactions proceed via a mechanistically unusual HAT reaction, where an association complex precedes hydrogen abstraction.

Original languageEnglish (US)
Pages (from-to)9513-9529
Number of pages17
JournalChemical Science
Volume10
Issue number41
DOIs
StatePublished - Jan 1 2019

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Iron
Oxidation
Electrons
Addition reactions
X ray absorption spectroscopy
Hydrocarbons
Computational methods
Sulfur
Oxidants
Discrete Fourier transforms
Molecular structure
Reaction rates
methyl(arginyl)-lysyl-prolyl-tryptophyl-tert-leucyl-leucine
Hydrogen
Nuclear magnetic resonance
Association reactions
Single crystals
X ray diffraction
Atoms
Molecules

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Sabenya, G., Gamba, I., Gómez, L., Clémancey, M., Frisch, J. R., Klinker, E. J., ... Costas, M. (2019). Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity. Chemical Science, 10(41), 9513-9529. https://doi.org/10.1039/c9sc02526j

Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity. / Sabenya, Gerard; Gamba, Ilaria; Gómez, Laura; Clémancey, Martin; Frisch, Jonathan R.; Klinker, Eric J.; Blondin, Geneviève; Torelli, Stéphane; Que, Lawrence; Martin-Diaconescu, Vlad; Latour, Jean Marc; Lloret-Fillol, Julio; Costas, Miquel.

In: Chemical Science, Vol. 10, No. 41, 01.01.2019, p. 9513-9529.

Research output: Contribution to journalArticle

Sabenya, G, Gamba, I, Gómez, L, Clémancey, M, Frisch, JR, Klinker, EJ, Blondin, G, Torelli, S, Que, L, Martin-Diaconescu, V, Latour, JM, Lloret-Fillol, J & Costas, M 2019, 'Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity', Chemical Science, vol. 10, no. 41, pp. 9513-9529. https://doi.org/10.1039/c9sc02526j
Sabenya G, Gamba I, Gómez L, Clémancey M, Frisch JR, Klinker EJ et al. Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity. Chemical Science. 2019 Jan 1;10(41):9513-9529. https://doi.org/10.1039/c9sc02526j
Sabenya, Gerard ; Gamba, Ilaria ; Gómez, Laura ; Clémancey, Martin ; Frisch, Jonathan R. ; Klinker, Eric J. ; Blondin, Geneviève ; Torelli, Stéphane ; Que, Lawrence ; Martin-Diaconescu, Vlad ; Latour, Jean Marc ; Lloret-Fillol, Julio ; Costas, Miquel. / Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity. In: Chemical Science. 2019 ; Vol. 10, No. 41. pp. 9513-9529.
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title = "Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity",
abstract = "High valent iron species are very reactive molecules involved in oxidation reactions of relevance to biology and chemical synthesis. Herein we describe iron(iv)-tosylimido complexes [FeIV(NTs)(MePy2tacn)](OTf)2 (1(IV)NTs) and [FeIV(NTs)(Me2(CHPy2)tacn)](OTf)2 (2(IV)NTs), (MePy2tacn = N-methyl-N,N-bis(2-picolyl)-1,4,7-triazacyclononane, and Me2(CHPy2)tacn = 1-(di(2-pyridyl)methyl)-4,7-dimethyl-1,4,7-triazacyclononane, Ts = Tosyl). 1(IV)NTs and 2(IV)NTs are rare examples of octahedral iron(iv)-imido complexes and are isoelectronic analogues of the recently described iron(iv)-oxo complexes [FeIV(O)(L)]2+ (L = MePy2tacn and Me2(CHPy2)tacn, respectively). 1(IV)NTs and 2(IV)NTs are metastable and have been spectroscopically characterized by HR-MS, UV-vis, 1H-NMR, resonance Raman, M{\"o}ssbauer, and X-ray absorption (XAS) spectroscopy as well as by DFT computational methods. Ferric complexes [FeIII(HNTs)(L)]2+, 1(III)-NHTs (L = MePy2tacn) and 2(III)-NHTs (L = Me2(CHPy2)tacn) have been isolated after the decay of 1(IV)NTs and 2(IV)NTs in solution, spectroscopically characterized, and the molecular structure of [FeIII(HNTs)(MePy2tacn)](SbF6)2 determined by single crystal X-ray diffraction. Reaction of 1(IV)NTs and 2(IV)NTs with different p-substituted thioanisoles results in the transfer of the tosylimido moiety to the sulphur atom producing sulfilimine products. In these reactions, 1(IV)NTs and 2(IV)NTs behave as single electron oxidants and Hammett analyses of reaction rates evidence that tosylimido transfer is more sensitive than oxo transfer to charge effects. In addition, reaction of 1(IV)NTs and 2(IV)NTs with hydrocarbons containing weak C-H bonds results in the formation of 1(III)-NHTs and 2(III)-NHTs respectively, along with the oxidized substrate. Kinetic analyses indicate that reactions proceed via a mechanistically unusual HAT reaction, where an association complex precedes hydrogen abstraction.",
author = "Gerard Sabenya and Ilaria Gamba and Laura G{\'o}mez and Martin Cl{\'e}mancey and Frisch, {Jonathan R.} and Klinker, {Eric J.} and Genevi{\`e}ve Blondin and St{\'e}phane Torelli and Lawrence Que and Vlad Martin-Diaconescu and Latour, {Jean Marc} and Julio Lloret-Fillol and Miquel Costas",
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TY - JOUR

T1 - Octahedral iron(iv)-tosylimido complexes exhibiting single electron-oxidation reactivity

AU - Sabenya, Gerard

AU - Gamba, Ilaria

AU - Gómez, Laura

AU - Clémancey, Martin

AU - Frisch, Jonathan R.

AU - Klinker, Eric J.

AU - Blondin, Geneviève

AU - Torelli, Stéphane

AU - Que, Lawrence

AU - Martin-Diaconescu, Vlad

AU - Latour, Jean Marc

AU - Lloret-Fillol, Julio

AU - Costas, Miquel

PY - 2019/1/1

Y1 - 2019/1/1

N2 - High valent iron species are very reactive molecules involved in oxidation reactions of relevance to biology and chemical synthesis. Herein we describe iron(iv)-tosylimido complexes [FeIV(NTs)(MePy2tacn)](OTf)2 (1(IV)NTs) and [FeIV(NTs)(Me2(CHPy2)tacn)](OTf)2 (2(IV)NTs), (MePy2tacn = N-methyl-N,N-bis(2-picolyl)-1,4,7-triazacyclononane, and Me2(CHPy2)tacn = 1-(di(2-pyridyl)methyl)-4,7-dimethyl-1,4,7-triazacyclononane, Ts = Tosyl). 1(IV)NTs and 2(IV)NTs are rare examples of octahedral iron(iv)-imido complexes and are isoelectronic analogues of the recently described iron(iv)-oxo complexes [FeIV(O)(L)]2+ (L = MePy2tacn and Me2(CHPy2)tacn, respectively). 1(IV)NTs and 2(IV)NTs are metastable and have been spectroscopically characterized by HR-MS, UV-vis, 1H-NMR, resonance Raman, Mössbauer, and X-ray absorption (XAS) spectroscopy as well as by DFT computational methods. Ferric complexes [FeIII(HNTs)(L)]2+, 1(III)-NHTs (L = MePy2tacn) and 2(III)-NHTs (L = Me2(CHPy2)tacn) have been isolated after the decay of 1(IV)NTs and 2(IV)NTs in solution, spectroscopically characterized, and the molecular structure of [FeIII(HNTs)(MePy2tacn)](SbF6)2 determined by single crystal X-ray diffraction. Reaction of 1(IV)NTs and 2(IV)NTs with different p-substituted thioanisoles results in the transfer of the tosylimido moiety to the sulphur atom producing sulfilimine products. In these reactions, 1(IV)NTs and 2(IV)NTs behave as single electron oxidants and Hammett analyses of reaction rates evidence that tosylimido transfer is more sensitive than oxo transfer to charge effects. In addition, reaction of 1(IV)NTs and 2(IV)NTs with hydrocarbons containing weak C-H bonds results in the formation of 1(III)-NHTs and 2(III)-NHTs respectively, along with the oxidized substrate. Kinetic analyses indicate that reactions proceed via a mechanistically unusual HAT reaction, where an association complex precedes hydrogen abstraction.

AB - High valent iron species are very reactive molecules involved in oxidation reactions of relevance to biology and chemical synthesis. Herein we describe iron(iv)-tosylimido complexes [FeIV(NTs)(MePy2tacn)](OTf)2 (1(IV)NTs) and [FeIV(NTs)(Me2(CHPy2)tacn)](OTf)2 (2(IV)NTs), (MePy2tacn = N-methyl-N,N-bis(2-picolyl)-1,4,7-triazacyclononane, and Me2(CHPy2)tacn = 1-(di(2-pyridyl)methyl)-4,7-dimethyl-1,4,7-triazacyclononane, Ts = Tosyl). 1(IV)NTs and 2(IV)NTs are rare examples of octahedral iron(iv)-imido complexes and are isoelectronic analogues of the recently described iron(iv)-oxo complexes [FeIV(O)(L)]2+ (L = MePy2tacn and Me2(CHPy2)tacn, respectively). 1(IV)NTs and 2(IV)NTs are metastable and have been spectroscopically characterized by HR-MS, UV-vis, 1H-NMR, resonance Raman, Mössbauer, and X-ray absorption (XAS) spectroscopy as well as by DFT computational methods. Ferric complexes [FeIII(HNTs)(L)]2+, 1(III)-NHTs (L = MePy2tacn) and 2(III)-NHTs (L = Me2(CHPy2)tacn) have been isolated after the decay of 1(IV)NTs and 2(IV)NTs in solution, spectroscopically characterized, and the molecular structure of [FeIII(HNTs)(MePy2tacn)](SbF6)2 determined by single crystal X-ray diffraction. Reaction of 1(IV)NTs and 2(IV)NTs with different p-substituted thioanisoles results in the transfer of the tosylimido moiety to the sulphur atom producing sulfilimine products. In these reactions, 1(IV)NTs and 2(IV)NTs behave as single electron oxidants and Hammett analyses of reaction rates evidence that tosylimido transfer is more sensitive than oxo transfer to charge effects. In addition, reaction of 1(IV)NTs and 2(IV)NTs with hydrocarbons containing weak C-H bonds results in the formation of 1(III)-NHTs and 2(III)-NHTs respectively, along with the oxidized substrate. Kinetic analyses indicate that reactions proceed via a mechanistically unusual HAT reaction, where an association complex precedes hydrogen abstraction.

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