Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis

Keyphrases

• Cysteine 100%
• Racemization 100%
• Solid-phase Peptide Synthesis 100%
• 1-Hydroxybenzotriazole 100%
• Hexafluorophosphate 66%
• Pre-activation 66%
• Dichloromethane 50%
• Dimethylamino 50%
• Dimethylformamide 50%
• Tris 33%
• Methylene 33%
• HOBt 33%
• Phosphonium 33%
• N-oxides 33%
• N-methylmorpholine 33%
• Methyl 16%
• Coupling Method 16%
• Quantitative Model 16%
• Thiols 16%
• Protecting Groups 16%
• Weak Base 16%
• Conventional Wisdom 16%
• Tertiary Amine 16%
• Peptide Synthesis 16%
• Model Peptide 16%
• Pentafluorophenyl Ester 16%
• N,N-dimethylformamide 16%
• Trityl 16%
• Aminium Salts 16%
• L-peptide 16%
• Coupling Conditions 16%
• Phosphonium Salts 16%
• Addition Strategy 16%
• N,N-diisopropylethylamine 16%
• L-Cys 16%
• Benzotriazol 16%
• HPLC Resolution 16%
• Collidine 16%
• 1H-1 16%

Chemistry

• Racemization 100%
• Peptide Synthesis 100%
• Cysteine 100%
• Phosphonium 60%
• Base 60%
• Tris 40%
• N-Oxide 40%
• TMP 40%
• Carbene 40%
• N,N-Dimethylformamide 20%
• Tertiary Amine 20%
• High Performance Liquid Chromatography 20%
• Protecting Groups 20%
• Thiol 20%