Occupation and Semen Parameters in a Cohort of Fertile Men

John D. Meyer; Charlene Brazil; J. Bruce Redmon; Christina Wang; Amy E. Sparks; Shanna H. Swan

doi:10.1097/JOM.0000000000002607

Occupation and Semen Parameters in a Cohort of Fertile Men

John D. Meyer
, Charlene Brazil
, J. Bruce Redmon
, Christina Wang
, Amy E. Sparks
, Shanna H. Swan

Medicine - Endocrine and Diabetes Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objective We examined associations between occupation and semen parameters in demonstrably fertile men in the Study for Future Families. Methods Associations of occupation and workplace exposures with semen volume, sperm concentration, motility, and morphology were assessed using generalized linear modeling. Results Lower sperm concentration and motility were seen in installation, maintenance, and repair occupations. Higher exposure to lead, and to other toxicants, was seen in occupations with lower mean sperm concentrations (prevalence ratio for lead: 4.1; pesticides/insecticides: 1.6; solvents: 1.4). Working with lead for more than 3 months was associated with lower sperm concentration, as was lead exposure outside of work. Conclusions We found evidence in demonstrably fertile men for reduced sperm quality with lead, pesticide/herbicide, and solvent exposure. These results may identify occupations where protective measures against male reproductive toxicity might be warranted.

Original language	English (US)
Pages (from-to)	831-838
Number of pages	8
Journal	Journal of Occupational and Environmental Medicine
Volume	64
Issue number	10
DOIs	https://doi.org/10.1097/JOM.0000000000002607
State	Published - Oct 1 2022

Bibliographical note

Funding Information:
Funding sources: This work was supported by the following grants from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and the National Institutes of Health (OH011540) (Icahn School of Medicine at Mount Sinai) and ES09916 (University of Missouri).

Funding Information:
Conflicts of Interest: Amy E. Sparks acknowledges support from Ferring Pharmaceuticals. J. Bruce Redmon and Shanna Swan were supported on the original Study for Future Families work by National Institute of Environmental Health Sciences grant ES09916.

Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

infertility
occupational exposures
occupational reproductive hazards

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10.1097/JOM.0000000000002607

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title = "Occupation and Semen Parameters in a Cohort of Fertile Men",

abstract = "Objective We examined associations between occupation and semen parameters in demonstrably fertile men in the Study for Future Families. Methods Associations of occupation and workplace exposures with semen volume, sperm concentration, motility, and morphology were assessed using generalized linear modeling. Results Lower sperm concentration and motility were seen in installation, maintenance, and repair occupations. Higher exposure to lead, and to other toxicants, was seen in occupations with lower mean sperm concentrations (prevalence ratio for lead: 4.1; pesticides/insecticides: 1.6; solvents: 1.4). Working with lead for more than 3 months was associated with lower sperm concentration, as was lead exposure outside of work. Conclusions We found evidence in demonstrably fertile men for reduced sperm quality with lead, pesticide/herbicide, and solvent exposure. These results may identify occupations where protective measures against male reproductive toxicity might be warranted.",

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author = "Meyer, \{John D.\} and Charlene Brazil and Redmon, \{J. Bruce\} and Christina Wang and Sparks, \{Amy E.\} and Swan, \{Shanna H.\}",

note = "Funding Information: Funding sources: This work was supported by the following grants from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and the National Institutes of Health (OH011540) (Icahn School of Medicine at Mount Sinai) and ES09916 (University of Missouri). Funding Information: Conflicts of Interest: Amy E. Sparks acknowledges support from Ferring Pharmaceuticals. J. Bruce Redmon and Shanna Swan were supported on the original Study for Future Families work by National Institute of Environmental Health Sciences grant ES09916. Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",

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doi = "10.1097/JOM.0000000000002607",

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AU - Redmon, J. Bruce

AU - Wang, Christina

AU - Sparks, Amy E.

AU - Swan, Shanna H.

N1 - Funding Information: Funding sources: This work was supported by the following grants from the Centers for Disease Control and Prevention/National Institute for Occupational Safety and the National Institutes of Health (OH011540) (Icahn School of Medicine at Mount Sinai) and ES09916 (University of Missouri). Funding Information: Conflicts of Interest: Amy E. Sparks acknowledges support from Ferring Pharmaceuticals. J. Bruce Redmon and Shanna Swan were supported on the original Study for Future Families work by National Institute of Environmental Health Sciences grant ES09916. Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Objective We examined associations between occupation and semen parameters in demonstrably fertile men in the Study for Future Families. Methods Associations of occupation and workplace exposures with semen volume, sperm concentration, motility, and morphology were assessed using generalized linear modeling. Results Lower sperm concentration and motility were seen in installation, maintenance, and repair occupations. Higher exposure to lead, and to other toxicants, was seen in occupations with lower mean sperm concentrations (prevalence ratio for lead: 4.1; pesticides/insecticides: 1.6; solvents: 1.4). Working with lead for more than 3 months was associated with lower sperm concentration, as was lead exposure outside of work. Conclusions We found evidence in demonstrably fertile men for reduced sperm quality with lead, pesticide/herbicide, and solvent exposure. These results may identify occupations where protective measures against male reproductive toxicity might be warranted.

AB - Objective We examined associations between occupation and semen parameters in demonstrably fertile men in the Study for Future Families. Methods Associations of occupation and workplace exposures with semen volume, sperm concentration, motility, and morphology were assessed using generalized linear modeling. Results Lower sperm concentration and motility were seen in installation, maintenance, and repair occupations. Higher exposure to lead, and to other toxicants, was seen in occupations with lower mean sperm concentrations (prevalence ratio for lead: 4.1; pesticides/insecticides: 1.6; solvents: 1.4). Working with lead for more than 3 months was associated with lower sperm concentration, as was lead exposure outside of work. Conclusions We found evidence in demonstrably fertile men for reduced sperm quality with lead, pesticide/herbicide, and solvent exposure. These results may identify occupations where protective measures against male reproductive toxicity might be warranted.

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KW - occupational exposures

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Occupation and Semen Parameters in a Cohort of Fertile Men

Abstract

Bibliographical note

UN SDGs

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