Occlusive vasculitis in a patient with concomitant West Nile virus infection

Peter K. Kaiser, Michael S. Lee, Denise A. Martin

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

PURPOSE: To describe a patient with occlusive, retinal vasculitis and concomitant, confirmed, acute West Nile virus (WNV) infection. DESIGN: Observational case report. METHODS: Main outcome measures included comprehensive ophthalmic examination with fluorescein angiography, color photography, and serologic testing for WNV and St. Louis encephalitis (SLE) virus including plaque reduction neutralization testing (PRNT). RESULTS: A 46-year-old woman developed a sudden decrease in vision in her left eye 2 weeks after confirmed WNV infection and demonstrated multiple, small, patchy areas of retinal edema with scattered microaneurysms. Fluorescein angiography showed multiple branch artery occlusions with extensive nonperfusion. Serologic titers for WNV were positive for acute infection. Plaque reduction neutralization testing confirmed WNV infection and excluded St. Louis encephalitis virus infection. Other etiologies of occlusive vasculitis were not present. CONCLUSION: Occlusive, retinal vasculitis may occur in the setting of acute WNV infection.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalAmerican journal of ophthalmology
Volume136
Issue number5
DOIs
StatePublished - Nov 2003

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