Obstructive Lung Diseases in HIV: A Clinical Review and Identification of Key Future Research Needs

M. Bradley Drummond, Ken M. Kunisaki, Laurence Huang

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33 Scopus citations


HIV infection has shifted from what was once a disease directly impacting short-term mortality to what is now a chronic illness controllable in the era of effective combination antiretroviral therapy (ART). In this setting, life expectancy for HIV-infected individual is nearly comparable to that of individuals without HIV. Subsequent to this increase in life expectancy, there has been recognition of increased multimorbidity among HIV-infected persons, with prevalence of comorbid chronic illnesses now approaching 65%. Obstructive lung diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are prevalent conditions associated with substantial morbidity and mortality in the United States. There is overlap in risk factors for HIV acquisition and chronic lung diseases, including lower socioeconomic status and the use of tobacco and illicit drugs. Objectives of this review are to (1) summarize the current state of knowledge regarding COPD and asthma among HIV-infected persons, (2) highlight implications for clinicians caring for patients with these combined comorbidities, and (3) identify key research initiatives to reduce the burden of obstructive lung diseases among HIV-infected persons.

Original languageEnglish (US)
Article number01210
Pages (from-to)277-288
Number of pages12
JournalSeminars in Respiratory and Critical Care Medicine
Issue number2
StatePublished - Apr 1 2016

Bibliographical note

Funding Information:
Dr. Drummond is supported by NIH grants U01 HL121814, R01 HL126549, U01 DA036297, and R01 HL125432–01A1. Dr. Kunisaki is supported by NIH grant R01 HL096453 and the Minneapolis VA Office of Research. Dr. Huang is supported by NIH grants K24 HL087713, R01 HL090335, U01 HL098964, and R01 HL128156.


  • COPD
  • HIV infection
  • asthma
  • comorbidities
  • obstructive lung disease


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