Observation of vascular injury after freezing: investigating the response of normal skin and subcutaneous AT-1 tumor tissue to cryosurgery in the dorsal skin flap chamber

Nathan E. Hoffmann, David J. Swanlund, John C. Bischof

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A study was performed to test the hypothesis that host response injury, specifically vascular injury, causes the majority of tissue necrosis at the edge of a frozen region and therefore determines the size of the lesion seen after in vivo freezing. The dorsal skin flap chamber (DSFC) implanted in the Copenhagen rat served as the cryosurgical model. There was a statistical correlation between the region of vascular stasis and the region of tissue necrosis, and the lesion sizes were statistically similar for tumor and normal tissue which are dissimilar save for the presence of a vasculature. The minimum temperature required to cause this damage was much higher than the temperature required for AT-1 cell destruction in vitro, and was similar to temperatures which caused vascular injury in other studies. These results lend support to the addressed hypothesis.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages39-41
Number of pages3
Volume44
ISBN (Print)0791816435
StatePublished - Dec 1 1999
EventAdvances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition) - Nashville, TN, USA
Duration: Nov 14 1999Nov 19 1999

Other

OtherAdvances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition)
CityNashville, TN, USA
Period11/14/9911/19/99

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