Observation of a second phosphate pool in the perfused heart by 31P NMR; is this the mitochondrial phosphate?

Pamela B. Garlick, Truman R. Brown, Richard H. Sullivan, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We report here our observations on perfused rat hearts using 31P NMR which show that inorganic phosphate (Pi) is located in two regions of differing pH. From the chemical shifts of the Pi signals and their behaviour under various stimuli we identify one signal (pH 7.0) as coming from the cytosol and suggest that the other (pH 7.38) comes from the mitochondrial matrix space.

Original languageEnglish (US)
Pages (from-to)855-858
Number of pages4
JournalJournal of Molecular and Cellular Cardiology
Volume15
Issue number12
DOIs
StatePublished - Dec 1983
Externally publishedYes

Bibliographical note

Funding Information:
by NSF and NIH

Keywords

  • Mitochondrial pH
  • Valinomycin

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