Objective measurement of adherence to out-patient airway clearance therapy by high-frequency chest wall compression in cystic fibrosis

Christina L. Mikesell, Robert R. Kempainen, Theresa A. Laguna, Jeremiah S. Menk, Andrew R. Wey, Philippe R. Gaillard, Warren E. Regelmann

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


BACKGROUND: Objective measures of adherence to high-frequency chest wall compression (HFCWC), a form of airway clearance therapy for patients with cystic fibrosis, are lacking. We used a novel electronic monitoring device integrated into an HFCWC vest to measure adherence compared with self-reported adherence. We determined factors that influenced adherence and how adherence correlated with baseline pulmonary function and pulmonary exacerbations. METHODS: Data were collected by direct measurement of date, time of day, and duration of HFCWC use to determine the number of daily treatments and daily duration of treatments. Chart review provided prescribed airway clearance therapy treatment and demographic and clinical information. Subject and caregiver report of the daily number of airway clearance therapy treatments was obtained by telephone interviews. Analysis used 2-sample and paired t test, analysis of variance, and linear regression. RESULTS: Average adherence was 69%. Adherence was highest in children (82%, P ☓.02) and those receiving assistance with treatment (82%, P <.001). Subjects overestimated therapy duration from a mean = SD of 127 = 169% by adults to 19.2 = 26.3% by parents or guardians of children. Average adherence decreased with increasing prescribed therapy time (P ☓.02). Average daily therapy time and adherence had significant positive associations with baseline FEV1 percent of predicted (P ☓.02 and P ☓.02, respectively) and negative associations with pulmonary exacerbations during the pre-study period and at baseline (P ☓.044 and P ☓.02, respectively). CONCLUSIONS: Greater adherence to HFCWC measured directly by a novel recorder was associated with better baseline pulmonary function and fewer exacerbations in the pre-study and baseline period. Adherence decreased with age and prescribed therapy time and increased with therapy assistance. Self-report overestimation is large and thus not an accurate measure of adherence.

Original languageEnglish (US)
Pages (from-to)920-927
Number of pages8
JournalRespiratory care
Issue number7
StatePublished - Jul 2017

Bibliographical note

Funding Information:
This study was supported in part by grants from the Cystic Fibrosis Foundation and from Hill-Rom, which also provided equipment and assistance in data collection. Dr Laguna has disclosed relationships with the National Institutes of Health, the Cystic Fibrosis Foundation, the Robert Wood Johnson Foundation, the Minnesota Medical Foundation, and Cayston Pharmaceuticals. The other authors have disclosed no conflicts of interest. We thank Lisa Henn PhD for statistical assistance, Ann Hazelwood CRT and Cynthia Williams CCRC for assistance in recruitment, and Marilyn Joseph MD for review of the manuscript.

Publisher Copyright:
© 2017 Daedalus Enterprises.


  • Adherence
  • Cystic fibrosis
  • High-frequency chest wall compression
  • Pulmonary exacerbation
  • Pulmonary function test


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