Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry

Jeff Min; Rui Feng; David Badesch; Erika Berman-Rosenzweig; Charles Burger; Murali Chakinala; Teresa De Marco; Jeremy Feldman; Anna Hemnes; Evelyn M. Horn; Matthew Lammi; Stephen Mathai; John W. McConnell; Kenneth Presberg; Jeffrey Robinson; Jeffrey Sager; Oksana Shlobin; Marc Simon; Thenappan Thenappan; Corey Ventetuolo; Nadine Al-Naamani

doi:10.1513/annalsats.202006-612oc

Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry

Jeff Min, Rui Feng, David Badesch, Erika Berman-Rosenzweig, Charles Burger, Murali Chakinala, Teresa De Marco, Jeremy Feldman, Anna Hemnes, Evelyn M. Horn, Matthew Lammi, Stephen Mathai, John W. McConnell, Kenneth Presberg, Jeffrey Robinson, Jeffrey Sager, Oksana Shlobin, Marc Simon, Thenappan Thenappan, Corey VentetuoloNadine Al-Naamani

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

RATIONALE: Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.

OBJECTIVES: To assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.

METHODS: We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.

RESULTS: 767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p<0.001). The overweight and obese have a trend towards increased incidence of hospitalizations compared to normal weight (IRR 1.34, 95% confidence interval (95%CI) 0.94-1.92 and 1.33, 95%CI 0.93-1.89, respectively). Overweight and obese patients had lower risk of transplant or death as compared to normal weight patients (HR 0.45, 95%CI 0.25-0.80 and 0.39, 95%CI 0.22-0.70, respectively).

CONCLUSIONS: In a large multicenter, prospective cohort of PAH, overweight and obese patients had worse disease-specific HRQoL despite better transplant-free survival compared to normal weight patients. Future interventions should address the specific needs of these patients.

Original language	English (US)
Pages (from-to)	229-237
Number of pages	9
Journal	Annals of the American Thoracic Society
Volume	18
Issue number	2
Early online date	Oct 21 2020
DOIs	https://doi.org/10.1513/annalsats.202006-612oc
State	Published - Feb 1 2021

Bibliographical note

Publisher Copyright:
© 2021 by the American Thoracic Society.

Keywords

Hospitalization
Obesity
Pulmonary arterial hypertension
Quality of life
Survival analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1513/annalsats.202006-612oc

Find It

Find It at U of M Libraries

Cite this

Min, J., Feng, R., Badesch, D., Berman-Rosenzweig, E., Burger, C., Chakinala, M., De Marco, T., Feldman, J., Hemnes, A., Horn, E. M., Lammi, M., Mathai, S., McConnell, J. W., Presberg, K., Robinson, J., Sager, J., Shlobin, O., Simon, M., Thenappan, T., ... Al-Naamani, N. (2021). Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry. Annals of the American Thoracic Society, 18(2), 229-237. https://doi.org/10.1513/annalsats.202006-612oc

Min, J, Feng, R, Badesch, D, Berman-Rosenzweig, E, Burger, C, Chakinala, M, De Marco, T, Feldman, J, Hemnes, A, Horn, EM, Lammi, M, Mathai, S, McConnell, JW, Presberg, K, Robinson, J, Sager, J, Shlobin, O, Simon, M, Thenappan, T, Ventetuolo, C & Al-Naamani, N 2021, 'Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry', Annals of the American Thoracic Society, vol. 18, no. 2, pp. 229-237. https://doi.org/10.1513/annalsats.202006-612oc

@article{859e9b566a3b4001b99f7ec7e8ff4840,

title = "Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry",

abstract = "RATIONALE: Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.OBJECTIVES: To assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.METHODS: We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.RESULTS: 767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p<0.001). The overweight and obese have a trend towards increased incidence of hospitalizations compared to normal weight (IRR 1.34, 95% confidence interval (95%CI) 0.94-1.92 and 1.33, 95%CI 0.93-1.89, respectively). Overweight and obese patients had lower risk of transplant or death as compared to normal weight patients (HR 0.45, 95%CI 0.25-0.80 and 0.39, 95%CI 0.22-0.70, respectively).CONCLUSIONS: In a large multicenter, prospective cohort of PAH, overweight and obese patients had worse disease-specific HRQoL despite better transplant-free survival compared to normal weight patients. Future interventions should address the specific needs of these patients.",

keywords = "Hospitalization, Obesity, Pulmonary arterial hypertension, Quality of life, Survival analysis",

author = "Jeff Min and Rui Feng and David Badesch and Erika Berman-Rosenzweig and Charles Burger and Murali Chakinala and {De Marco}, Teresa and Jeremy Feldman and Anna Hemnes and Horn, {Evelyn M.} and Matthew Lammi and Stephen Mathai and McConnell, {John W.} and Kenneth Presberg and Jeffrey Robinson and Jeffrey Sager and Oksana Shlobin and Marc Simon and Thenappan Thenappan and Corey Ventetuolo and Nadine Al-Naamani",

note = "Publisher Copyright: {\textcopyright} 2021 by the American Thoracic Society.",

year = "2021",

month = feb,

day = "1",

doi = "10.1513/annalsats.202006-612oc",

language = "English (US)",

volume = "18",

pages = "229--237",

journal = "Annals of the American Thoracic Society",

issn = "2329-6933",

publisher = "American Thoracic Society",

number = "2",

}

TY - JOUR

T1 - Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry

AU - Min, Jeff

AU - Feng, Rui

AU - Badesch, David

AU - Berman-Rosenzweig, Erika

AU - Burger, Charles

AU - Chakinala, Murali

AU - De Marco, Teresa

AU - Feldman, Jeremy

AU - Hemnes, Anna

AU - Horn, Evelyn M.

AU - Lammi, Matthew

AU - Mathai, Stephen

AU - McConnell, John W.

AU - Presberg, Kenneth

AU - Robinson, Jeffrey

AU - Sager, Jeffrey

AU - Shlobin, Oksana

AU - Simon, Marc

AU - Thenappan, Thenappan

AU - Ventetuolo, Corey

AU - Al-Naamani, Nadine

PY - 2021/2/1

Y1 - 2021/2/1

N2 - RATIONALE: Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.OBJECTIVES: To assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.METHODS: We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.RESULTS: 767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p<0.001). The overweight and obese have a trend towards increased incidence of hospitalizations compared to normal weight (IRR 1.34, 95% confidence interval (95%CI) 0.94-1.92 and 1.33, 95%CI 0.93-1.89, respectively). Overweight and obese patients had lower risk of transplant or death as compared to normal weight patients (HR 0.45, 95%CI 0.25-0.80 and 0.39, 95%CI 0.22-0.70, respectively).CONCLUSIONS: In a large multicenter, prospective cohort of PAH, overweight and obese patients had worse disease-specific HRQoL despite better transplant-free survival compared to normal weight patients. Future interventions should address the specific needs of these patients.

AB - RATIONALE: Obesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.OBJECTIVES: To assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.METHODS: We performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.RESULTS: 767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p<0.001). The overweight and obese have a trend towards increased incidence of hospitalizations compared to normal weight (IRR 1.34, 95% confidence interval (95%CI) 0.94-1.92 and 1.33, 95%CI 0.93-1.89, respectively). Overweight and obese patients had lower risk of transplant or death as compared to normal weight patients (HR 0.45, 95%CI 0.25-0.80 and 0.39, 95%CI 0.22-0.70, respectively).CONCLUSIONS: In a large multicenter, prospective cohort of PAH, overweight and obese patients had worse disease-specific HRQoL despite better transplant-free survival compared to normal weight patients. Future interventions should address the specific needs of these patients.

KW - Hospitalization

KW - Obesity

KW - Pulmonary arterial hypertension

KW - Quality of life

KW - Survival analysis

UR - http://www.scopus.com/inward/record.url?scp=85101173936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85101173936&partnerID=8YFLogxK

U2 - 10.1513/annalsats.202006-612oc

DO - 10.1513/annalsats.202006-612oc

M3 - Article

C2 - 33085915

AN - SCOPUS:85101173936

SN - 2329-6933

VL - 18

SP - 229

EP - 237

JO - Annals of the American Thoracic Society

JF - Annals of the American Thoracic Society

IS - 2

ER -

Obesity in pulmonary arterial hypertension the pulmonary hypertension association registry

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this