Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Joel Nuotio; Tomi T. Laitinen; Alan R Sinaiko; Jessica G. Woo; Elaine M. Urbina; David Jacobs; Julia Steinberger; Ronald J. Prineas; Matthew A. Sabin; David P. Burgner; Heikki Minn; Trudy L. Burns; Lydia A. Bazzano; Alison J. Venn; Jorma S.A. Viikari; Nina Hutri-Kähönen; Stephen R. Daniels; Olli T. Raitakari; Costan G. Magnussen; Markus Juonala; Terence Dwyer

doi:10.1038/s41366-021-01000-3

Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Joel Nuotio, Tomi T. Laitinen, Alan R Sinaiko, Jessica G. Woo, Elaine M. Urbina, David Jacobs, Julia Steinberger, Ronald J. Prineas, Matthew A. Sabin, David P. Burgner, Heikki Minn, Trudy L. Burns, Lydia A. Bazzano, Alison J. Venn, Jorma S.A. Viikari, Nina Hutri-Kähönen, Stephen R. Daniels, Olli T. Raitakari, Costan G. Magnussen, Markus JuonalaTerence Dwyer

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

Original language	English (US)
Pages (from-to)	393-399
Number of pages	7
Journal	International Journal of Obesity
Volume	46
Issue number	2
DOIs	https://doi.org/10.1038/s41366-021-01000-3
State	Published - Feb 2022

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (NIH; Grant No.: R01 HL121230). Harmonization and other data work before obtaining NIH funding were supported by the Australian National Health and Medical Research Council Project (Grant Nos.: APP1098369, APP211316), the Academy of Finland (Grant No.: 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, and Yrjö Jahnsson Foundation. The funders of this study had no role in the design and conduct of the study. Open Access funding provided by University of Turku (UTU) including Turku University Central Hospital.

Publisher Copyright:
© 2021, The Author(s).

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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

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Nuotio, J., Laitinen, T. T., Sinaiko, A. R., Woo, J. G., Urbina, E. M., Jacobs, D., Steinberger, J., Prineas, R. J., Sabin, M. A., Burgner, D. P., Minn, H., Burns, T. L., Bazzano, L. A., Venn, A. J., Viikari, J. S. A., Hutri-Kähönen, N., Daniels, S. R., Raitakari, O. T., Magnussen, C. G., ... Dwyer, T. (2022). Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium. International Journal of Obesity, 46(2), 393-399. https://doi.org/10.1038/s41366-021-01000-3

Nuotio, J, Laitinen, TT, Sinaiko, AR, Woo, JG, Urbina, EM, Jacobs, D , Steinberger, J, Prineas, RJ, Sabin, MA, Burgner, DP, Minn, H, Burns, TL, Bazzano, LA, Venn, AJ, Viikari, JSA, Hutri-Kähönen, N, Daniels, SR, Raitakari, OT, Magnussen, CG, Juonala, M & Dwyer, T 2022, 'Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium', International Journal of Obesity, vol. 46, no. 2, pp. 393-399. https://doi.org/10.1038/s41366-021-01000-3

@article{cb2adb916f54453f915bbe1235d0f156,

title = "Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium",

abstract = "Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.",

author = "Joel Nuotio and Laitinen, {Tomi T.} and Sinaiko, {Alan R} and Woo, {Jessica G.} and Urbina, {Elaine M.} and David Jacobs and Julia Steinberger and Prineas, {Ronald J.} and Sabin, {Matthew A.} and Burgner, {David P.} and Heikki Minn and Burns, {Trudy L.} and Bazzano, {Lydia A.} and Venn, {Alison J.} and Viikari, {Jorma S.A.} and Nina Hutri-K{\"a}h{\"o}nen and Daniels, {Stephen R.} and Raitakari, {Olli T.} and Magnussen, {Costan G.} and Markus Juonala and Terence Dwyer",

note = "Funding Information: This work was supported by the National Institutes of Health (NIH; Grant No.: R01 HL121230). Harmonization and other data work before obtaining NIH funding were supported by the Australian National Health and Medical Research Council Project (Grant Nos.: APP1098369, APP211316), the Academy of Finland (Grant No.: 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, and Yrj{\"o} Jahnsson Foundation. The funders of this study had no role in the design and conduct of the study. Open Access funding provided by University of Turku (UTU) including Turku University Central Hospital. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2022",

month = feb,

doi = "10.1038/s41366-021-01000-3",

language = "English (US)",

volume = "46",

pages = "393--399",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Obesity during childhood is associated with higher cancer mortality rate during adulthood

T2 - the i3C Consortium

AU - Nuotio, Joel

AU - Laitinen, Tomi T.

AU - Sinaiko, Alan R

AU - Woo, Jessica G.

AU - Urbina, Elaine M.

AU - Jacobs, David

AU - Steinberger, Julia

AU - Prineas, Ronald J.

AU - Sabin, Matthew A.

AU - Burgner, David P.

AU - Minn, Heikki

AU - Burns, Trudy L.

AU - Bazzano, Lydia A.

AU - Venn, Alison J.

AU - Viikari, Jorma S.A.

AU - Hutri-Kähönen, Nina

AU - Daniels, Stephen R.

AU - Raitakari, Olli T.

AU - Magnussen, Costan G.

AU - Juonala, Markus

AU - Dwyer, Terence

N1 - Funding Information: This work was supported by the National Institutes of Health (NIH; Grant No.: R01 HL121230). Harmonization and other data work before obtaining NIH funding were supported by the Australian National Health and Medical Research Council Project (Grant Nos.: APP1098369, APP211316), the Academy of Finland (Grant No.: 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, and Yrjö Jahnsson Foundation. The funders of this study had no role in the design and conduct of the study. Open Access funding provided by University of Turku (UTU) including Turku University Central Hospital. Publisher Copyright: © 2021, The Author(s).

PY - 2022/2

Y1 - 2022/2

N2 - Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

AB - Background: In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. Methods: We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3–19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries. Results: 354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.13; 95% confidence interval [CI] 1.03–1.24 per 1-SD increase) and childhood glucose (HR 1.22; 95%CI 1.01–1.47 per 1-SD increase), were associated with subsequent cancer mortality. In a multivariable analysis adjusted for age, sex, cohort, and childhood measures of fasting glucose, total cholesterol, triglycerides, and systolic blood pressure, childhood BMI remained as an independent predictor of subsequent cancer mortality (HR, 1.24; 95%CI, 1.03–1.49). The association of childhood BMI and subsequent cancer mortality persisted after adjustment for adulthood BMI (HR for childhood BMI, 1.35; 95%CI 1.12–1.63). Conclusions: Higher childhood BMI was independently associated with increased overall cancer mortality.

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DO - 10.1038/s41366-021-01000-3

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SN - 0307-0565

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SP - 393

EP - 399

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 2

ER -

Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium

Abstract

Bibliographical note

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UN SDGs

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