Obesity-asthma association

Is it explained by systemic oxidant stress?

Akshay Sood, Clifford Qualls, Alexander Arynchyn, William S. Beckett, Myron D. Gross, Michael W. Steffes, Lewis J. Smith, Paul Holvoet, Bharat Thyagarajan, David R. Jacobs

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The mechanism for the obesity-asthma association is unknown. This study evaluated the hypothesis that systemic oxidant stress explains this association. Methods: This cross-sectional study used year-20 follow-up evaluation data of 2,865 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Current asthma was self-reported. Oxidant stress primarily was assessed by plasma F2-isoprostane concentrations. Obesity measures included categories of BMI and dual-energy x-ray absorptiometry-assessed fat mass index (FMI) and lean mass index (LMI). Logistic and linear regressions were used for analyses. Results: Asthma was associated with higher plasma F2-isoprostane concentrations (p = 0.049); however, this association was not significant when adjusted for either gender or BMI. The BMI-asthma association was seen only among women (p = 0.03; gender-specific interaction, p = 0.01), and this association was not explained by plasma F2-isoprostane levels. Similarly, both FMI and LMI were positively associated with asthma in women (p = 0.20 and 0.01, respectively). These associations also were not explained by plasma F2-isoprostane levels. Similar results were obtained when plasma levels of oxidized low-density lipoprotein were used instead of F2-isoprostane levels to study the BMI-asthma association at the year-15 evaluation. Conclusions: Systemic oxidant stress, primarily assessed by plasma F2-isoprostane concentrations, was not independently associated with asthma and, therefore, may not explain the obesity-asthma association in women. The asthma-oxidant stress association is confounded by gender and obesity. This study is limited by the inability to measure airway oxidant stress. It is possible that another (as yet undetermined) measure of systemic oxidant stress may be more relevant in asthma.

Original languageEnglish (US)
Pages (from-to)1055-1062
Number of pages8
JournalChest
Volume136
Issue number4
DOIs
StatePublished - Oct 1 2009

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Oxidants
F2-Isoprostanes
Asthma
Obesity
Fats
Young Adult
Linear Models
Coronary Vessels
Cross-Sectional Studies
Logistic Models
X-Rays

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Obesity-asthma association : Is it explained by systemic oxidant stress? / Sood, Akshay; Qualls, Clifford; Arynchyn, Alexander; Beckett, William S.; Gross, Myron D.; Steffes, Michael W.; Smith, Lewis J.; Holvoet, Paul; Thyagarajan, Bharat; Jacobs, David R.

In: Chest, Vol. 136, No. 4, 01.10.2009, p. 1055-1062.

Research output: Contribution to journalArticle

Sood, A, Qualls, C, Arynchyn, A, Beckett, WS, Gross, MD, Steffes, MW, Smith, LJ, Holvoet, P, Thyagarajan, B & Jacobs, DR 2009, 'Obesity-asthma association: Is it explained by systemic oxidant stress?', Chest, vol. 136, no. 4, pp. 1055-1062. https://doi.org/10.1378/chest.09-0493
Sood, Akshay ; Qualls, Clifford ; Arynchyn, Alexander ; Beckett, William S. ; Gross, Myron D. ; Steffes, Michael W. ; Smith, Lewis J. ; Holvoet, Paul ; Thyagarajan, Bharat ; Jacobs, David R. / Obesity-asthma association : Is it explained by systemic oxidant stress?. In: Chest. 2009 ; Vol. 136, No. 4. pp. 1055-1062.
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abstract = "Background: The mechanism for the obesity-asthma association is unknown. This study evaluated the hypothesis that systemic oxidant stress explains this association. Methods: This cross-sectional study used year-20 follow-up evaluation data of 2,865 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Current asthma was self-reported. Oxidant stress primarily was assessed by plasma F2-isoprostane concentrations. Obesity measures included categories of BMI and dual-energy x-ray absorptiometry-assessed fat mass index (FMI) and lean mass index (LMI). Logistic and linear regressions were used for analyses. Results: Asthma was associated with higher plasma F2-isoprostane concentrations (p = 0.049); however, this association was not significant when adjusted for either gender or BMI. The BMI-asthma association was seen only among women (p = 0.03; gender-specific interaction, p = 0.01), and this association was not explained by plasma F2-isoprostane levels. Similarly, both FMI and LMI were positively associated with asthma in women (p = 0.20 and 0.01, respectively). These associations also were not explained by plasma F2-isoprostane levels. Similar results were obtained when plasma levels of oxidized low-density lipoprotein were used instead of F2-isoprostane levels to study the BMI-asthma association at the year-15 evaluation. Conclusions: Systemic oxidant stress, primarily assessed by plasma F2-isoprostane concentrations, was not independently associated with asthma and, therefore, may not explain the obesity-asthma association in women. The asthma-oxidant stress association is confounded by gender and obesity. This study is limited by the inability to measure airway oxidant stress. It is possible that another (as yet undetermined) measure of systemic oxidant stress may be more relevant in asthma.",
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AU - Gross, Myron D.

AU - Steffes, Michael W.

AU - Smith, Lewis J.

AU - Holvoet, Paul

AU - Thyagarajan, Bharat

AU - Jacobs, David R.

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