O-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by human UDP-glucuronosyltransferases 2B7 and 1A9

Keyphrases

• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 100%
• Carcinogen 100%
• Detoxification 16%
• Detoxification Pathways 16%
• Diastereomers 50%
• Expression Level 16%
• Gluc 66%
• Glucuronidation 16%
• Human Liver 50%
• Human Lung 33%
• Liver 33%
• Liver Specimen 16%
• Lung 100%
• Lung Specimen 33%
• Major Metabolites 16%
• Microsomal Fraction 33%
• Multiple Persons 16%
• O-glucuronidation 100%
• Overexpressing 100%
• Quantitative PCR 16%
• Significant Level 33%
• UDP-glucuronosyltransferase 100%
• UDP-glucuronosyltransferase (UGT) 1A9 100%
• UDP-glucuronosyltransferase (UGT) 2B7 100%
• UGT1A1 33%
• UGT1A10 16%
• UGT1A3 16%
• UGT1A4 16%
• UGT1A6 16%
• UGT1A7 16%
• UGT1A9 50%
• UGT2B15 16%
• UGT2B4 16%
• UGT2B7 83%
• V79 Cells 33%

Pharmacology, Toxicology and Pharmaceutical Science

• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanol 100%
• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanone 33%
• Carcinogen 100%
• Detoxication 66%
• Glucuronosyltransferase 1A9 100%
• Glucuronosyltransferase 2B7 100%
• RNA Directed DNA Polymerase 33%