Nutritional influences on brain development

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

There is increasing evidence from preclinical and human studies that nutrition in the late foetal and early neonatal period has a significant impact on neurodevelopment across the lifespan. Certain nutrients have particularly large effects in this time period, and their deficits cause greater long-term risk. The mechanisms by which nutrients influence early brain growth and the sensitive periods for when certain nutrients should be provided are being elucidated. Assessments of nutritional status that index brain growth and predict long-term development are important to assess the efficacy of early life nutritional therapies. Conclusion: Optimizing nutrition during foetal and early postnatal life is a golden opportunity to impact neurodevelopment and brain function across the lifespan.

Original languageEnglish (US)
Pages (from-to)1310-1321
Number of pages12
JournalActa Paediatrica, International Journal of Paediatrics
Volume107
Issue number8
DOIs
StatePublished - Aug 1 2018

Fingerprint

Food
Brain
Nutrition Assessment
Growth
Nutritional Status
Therapeutics

Keywords

  • Brain
  • Development
  • Foetus
  • Neonate
  • Nutrition

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Nutritional influences on brain development. / Georgieff, Michael K; Ramel, Sara E; Cusick, Sarah.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 107, No. 8, 01.08.2018, p. 1310-1321.

Research output: Contribution to journalReview article

@article{27f0a26e9ea14c5c9de3ccff139c17d1,
title = "Nutritional influences on brain development",
abstract = "There is increasing evidence from preclinical and human studies that nutrition in the late foetal and early neonatal period has a significant impact on neurodevelopment across the lifespan. Certain nutrients have particularly large effects in this time period, and their deficits cause greater long-term risk. The mechanisms by which nutrients influence early brain growth and the sensitive periods for when certain nutrients should be provided are being elucidated. Assessments of nutritional status that index brain growth and predict long-term development are important to assess the efficacy of early life nutritional therapies. Conclusion: Optimizing nutrition during foetal and early postnatal life is a golden opportunity to impact neurodevelopment and brain function across the lifespan.",
keywords = "Brain, Development, Foetus, Neonate, Nutrition",
author = "Georgieff, {Michael K} and Ramel, {Sara E} and Sarah Cusick",
year = "2018",
month = "8",
day = "1",
doi = "10.1111/apa.14287",
language = "English (US)",
volume = "107",
pages = "1310--1321",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Nutritional influences on brain development

AU - Georgieff, Michael K

AU - Ramel, Sara E

AU - Cusick, Sarah

PY - 2018/8/1

Y1 - 2018/8/1

N2 - There is increasing evidence from preclinical and human studies that nutrition in the late foetal and early neonatal period has a significant impact on neurodevelopment across the lifespan. Certain nutrients have particularly large effects in this time period, and their deficits cause greater long-term risk. The mechanisms by which nutrients influence early brain growth and the sensitive periods for when certain nutrients should be provided are being elucidated. Assessments of nutritional status that index brain growth and predict long-term development are important to assess the efficacy of early life nutritional therapies. Conclusion: Optimizing nutrition during foetal and early postnatal life is a golden opportunity to impact neurodevelopment and brain function across the lifespan.

AB - There is increasing evidence from preclinical and human studies that nutrition in the late foetal and early neonatal period has a significant impact on neurodevelopment across the lifespan. Certain nutrients have particularly large effects in this time period, and their deficits cause greater long-term risk. The mechanisms by which nutrients influence early brain growth and the sensitive periods for when certain nutrients should be provided are being elucidated. Assessments of nutritional status that index brain growth and predict long-term development are important to assess the efficacy of early life nutritional therapies. Conclusion: Optimizing nutrition during foetal and early postnatal life is a golden opportunity to impact neurodevelopment and brain function across the lifespan.

KW - Brain

KW - Development

KW - Foetus

KW - Neonate

KW - Nutrition

UR - http://www.scopus.com/inward/record.url?scp=85044220714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044220714&partnerID=8YFLogxK

U2 - 10.1111/apa.14287

DO - 10.1111/apa.14287

M3 - Review article

VL - 107

SP - 1310

EP - 1321

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 8

ER -