Nutrition and other risk factors for renal cell carcinoma in postmenopausal women

Ronald J. Prineas, Aaron R. Folsom, Zhu Ming Zhang, Thomas A. Sellers, John Potter

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Among 35,192 postmenopausal, predominantly white women in Iowa age 55- 69 years and free of cancer, we collected baseline history, dietary information, and anthropometric data by mail in 1986. We ascertained the 8- year incidence (62 new cases) of renal cell carcinoma using the Iowa Surveillance, Epidemiology, and End Results (SEER) register, the National Death Index, and mail follow-up. Risk factors for renal cell carcinoma included increasing age, increasing weight (either current, maximum adult weight, or weight at ages 18, 30, or 50 years), greater waist-to-hip ratio, and a history of blood transfusion. Total dietary calcium was associated independently with a reduced risk of renal cell carcinoma. No other dietary micro- or macronutrients or food groups were predictive of the development of renal cell carcinoma. Other previously identified risk factors were not confirmed: most notably, there was no increased risk from a history of hypertension, after adjustment for diuretic use. History of ever-use of diuretics was associated with a twofold increased risk of renal cancer, although the strength of association was markedly reduced after adjustment for age, weight, waist-to-hip ratio, and calcium intake.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
Issue number1
StatePublished - Jan 1997


  • age
  • body weight
  • cohort study
  • diuretics
  • minerals
  • postmenopausal women
  • renal carcinoma
  • vitamins


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