TY - JOUR
T1 - Nutrition and other risk factors for renal cell carcinoma in postmenopausal women
AU - Prineas, Ronald J.
AU - Folsom, Aaron R.
AU - Zhang, Zhu Ming
AU - Sellers, Thomas A.
AU - Potter, John
PY - 1997/1
Y1 - 1997/1
N2 - Among 35,192 postmenopausal, predominantly white women in Iowa age 55- 69 years and free of cancer, we collected baseline history, dietary information, and anthropometric data by mail in 1986. We ascertained the 8- year incidence (62 new cases) of renal cell carcinoma using the Iowa Surveillance, Epidemiology, and End Results (SEER) register, the National Death Index, and mail follow-up. Risk factors for renal cell carcinoma included increasing age, increasing weight (either current, maximum adult weight, or weight at ages 18, 30, or 50 years), greater waist-to-hip ratio, and a history of blood transfusion. Total dietary calcium was associated independently with a reduced risk of renal cell carcinoma. No other dietary micro- or macronutrients or food groups were predictive of the development of renal cell carcinoma. Other previously identified risk factors were not confirmed: most notably, there was no increased risk from a history of hypertension, after adjustment for diuretic use. History of ever-use of diuretics was associated with a twofold increased risk of renal cancer, although the strength of association was markedly reduced after adjustment for age, weight, waist-to-hip ratio, and calcium intake.
AB - Among 35,192 postmenopausal, predominantly white women in Iowa age 55- 69 years and free of cancer, we collected baseline history, dietary information, and anthropometric data by mail in 1986. We ascertained the 8- year incidence (62 new cases) of renal cell carcinoma using the Iowa Surveillance, Epidemiology, and End Results (SEER) register, the National Death Index, and mail follow-up. Risk factors for renal cell carcinoma included increasing age, increasing weight (either current, maximum adult weight, or weight at ages 18, 30, or 50 years), greater waist-to-hip ratio, and a history of blood transfusion. Total dietary calcium was associated independently with a reduced risk of renal cell carcinoma. No other dietary micro- or macronutrients or food groups were predictive of the development of renal cell carcinoma. Other previously identified risk factors were not confirmed: most notably, there was no increased risk from a history of hypertension, after adjustment for diuretic use. History of ever-use of diuretics was associated with a twofold increased risk of renal cancer, although the strength of association was markedly reduced after adjustment for age, weight, waist-to-hip ratio, and calcium intake.
KW - age
KW - body weight
KW - cohort study
KW - diuretics
KW - minerals
KW - postmenopausal women
KW - renal carcinoma
KW - vitamins
UR - http://www.scopus.com/inward/record.url?scp=0031012435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031012435&partnerID=8YFLogxK
U2 - 10.1097/00001648-199701000-00005
DO - 10.1097/00001648-199701000-00005
M3 - Article
C2 - 9116091
AN - SCOPUS:0031012435
SN - 1044-3983
VL - 8
SP - 31
EP - 36
JO - Epidemiology
JF - Epidemiology
IS - 1
ER -