Moringa oleifera Lam. (M. oleifera), which belongs to the Moringaceae family, is a perennial deciduous tropical tree, and native to the south of the Himalayan Mountains in northern India. M. oleifera is rich in proteins, vitamin A, minerals, essential amino acids, antioxidants, and flavonoids, as well as isothiocyanates. The extracts from M. oleifera exhibit multiple nutraceutical or pharmacological functions including anti-inflammatory, antioxidant, anti-cancer, hepatoprotective, neuroprotective, hypoglycemic, and blood lipid-reducing functions. The beneficial functions of M. oleifera are strongly associated with its phytochemicals such as flavonoids or isothiocyanates with bioactivity. In this review, we summarize the research progress related to the bioactivity and pharmacological mechanisms of M. oleifera in the prevention and treatment of a series of chronic diseases-including inflammatory diseases, neuro-dysfunctional diseases, diabetes, and cancers-which will provide a reference for its potential application in the prevention and treatment of chronic diseases or health promotion.
Bibliographical noteFunding Information:
Acknowledgments: This work was financially supported by the National Natural Science Foundation of China (No. 81601228); Natural Science Foundation from Science and Technology Department of Hubei Province (2017CFB553); and Donghu Scholar Program from Wuhan Sports University to Xianjuan Kou, as well as Hubei Superior Discipline Group of Physical Education and Health Promotion, and Outstanding Youth Scientific and Technological Innovation Team (T201624) from Hubei Provincial Department of Education; and Chutian Scholar Program and Innovative Start-Up Foundation from Wuhan Sports University to Ning Chen.
- Chronic disease
- Moringa oleifera
- Pharmacological potential