Number of synergies impacts sensitivity of gait to weakness and contracture

Elijah C. Kuska, Naser Mehrabi, Michael H. Schwartz, Katherine M. Steele

Research output: Contribution to journalArticlepeer-review

Abstract

Muscle activity during gait can be described by a small set of synergies, weighted groups of muscles, that are theorized to reflect underlying neural control. For people with neurologic injuries, like cerebral palsy or stroke, even fewer synergies are required to explain muscle activity during gait. This reduction in synergies is thought to reflect altered control and is associated with impairment severity and treatment outcomes. Individuals with neurologic injuries also develop secondary musculoskeletal impairments, like weakness or contracture, that can impact gait. Yet, the combined impacts of altered control and musculoskeletal impairments on gait remains unclear. In this study, we use a two-dimensional musculoskeletal model constrained to synergy control to simulate unimpaired gait. We vary the number of synergies, while simulating muscle weakness and contracture to examine how altered control impacts sensitivity to musculoskeletal impairment while tracking unimpaired gait. Results demonstrate that reducing the number of synergies increases sensitivity to weakness and contracture for specific muscle groups. For example, simulations using five-synergy control tolerated 40% and 51% more knee extensor weakness than those using four- or three-synergy control, respectively. Furthermore, when constrained to four- or three-synergy control, the model was increasingly sensitive to contracture and weakness of proximal muscles, such as the hamstring and hip flexors. Contrastingly, neither the amount of generalized nor plantarflexor weakness tolerated was affected by the number of synergies. These findings highlight the interactions between altered control and musculoskeletal impairments, emphasizing the importance of measuring and incorporating both in future simulation and experimental studies.

Original languageEnglish (US)
Article number111012
JournalJournal of Biomechanics
Volume134
DOIs
StatePublished - Mar 2022

Bibliographical note

Funding Information:
This research was supported by the National Institute of Neurological Disorders and Stroke (NINDS) under grant number R01NS091056 in collaboration with Gillette Children’s Specialty Healthcare. The authors would like to thank Megan Ebers, Anthony Anderson, and Michael Rosenberg for their insightful feedback.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Altered motor modules
  • Control Complexity
  • Impaired motor control
  • Musculoskeletal impairment
  • Walking simulation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Fingerprint

Dive into the research topics of 'Number of synergies impacts sensitivity of gait to weakness and contracture'. Together they form a unique fingerprint.

Cite this