Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Pierre Sonigo; Marc Alizon; Katherine Staskus; David Klatzmann; Stewart Cole; Olivier Danos; Ernest Retzel; Pierre Tiollais; Ashley Haase; Simon Wain-Hobson

doi:10.1016/S0092-8674(85)80132-X

Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Pierre Sonigo, Marc Alizon, Katherine Staskus, David Klatzmann, Stewart Cole, Olivier Danos, Ernest Retzel, Pierre Tiollais, Ashley Haase, Simon Wain-Hobson

Microbiology

Research output: Contribution to journal › Article › peer-review

442 Scopus citations

Abstract

We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

Original language	English (US)
Pages (from-to)	369-382
Number of pages	14
Journal	Cell
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/S0092-8674(85)80132-X
State	Published - Aug 1985

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abstract = "We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.",

author = "Pierre Sonigo and Marc Alizon and Katherine Staskus and David Klatzmann and Stewart Cole and Olivier Danos and Ernest Retzel and Pierre Tiollais and Ashley Haase and Simon Wain-Hobson",

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T2 - relationship to the AIDS virus

AU - Sonigo, Pierre

AU - Alizon, Marc

AU - Staskus, Katherine

AU - Klatzmann, David

AU - Cole, Stewart

AU - Danos, Olivier

AU - Retzel, Ernest

AU - Tiollais, Pierre

AU - Haase, Ashley

AU - Wain-Hobson, Simon

PY - 1985/8

Y1 - 1985/8

N2 - We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

AB - We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

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JO - Cell

JF - Cell

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Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus

Abstract

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