Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)1)

Krzysztofai W. Pankiewicz, Kyoichi A. Watanabe

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Treatment of 2,5’-anhydro-3’-O-acetyl-2’-O-triflyluridine with a nucleophile such as NaOAc, NaN3, LiCl or LiBr, did not afford the 2’-substituted 2,5’-anhydro-arabinosyluracil, but gave 2,2’-anhydro-l-(5-substituted-β-D-arabinofuranosyl)uracil instead.

Original languageEnglish (US)
Pages (from-to)4494-4497
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume35
Issue number11
DOIs
StatePublished - 1987

Keywords

  • 2‘-anhydroabinosyluracil new transformation
  • 2’-anhydrouracilnucleoside 2
  • 5‘-anhydro-3‘-O-acetyl-2‘
  • 5’-anhydrouracilnucleoside 2
  • O-triflyluridine 5‘-substituted-2
  • nucleoside anhydronucleoside 2

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