Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)1)

Krzysztofai W. Pankiewicz; Kyoichi A. Watanabe

doi:10.1248/cpb.35.4494

Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)¹⁾

Krzysztofai W. Pankiewicz, Kyoichi A. Watanabe

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Treatment of 2,5’-anhydro-3’-O-acetyl-2’-O-triflyluridine with a nucleophile such as NaOAc, NaN₃, LiCl or LiBr, did not afford the 2’-substituted 2,5’-anhydro-arabinosyluracil, but gave 2,2’-anhydro-l-(5-substituted-β-D-arabinofuranosyl)uracil instead.

Original language	English (US)
Pages (from-to)	4494-4497
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	11
DOIs	https://doi.org/10.1248/cpb.35.4494
State	Published - 1987
Externally published	Yes

Keywords

2‘-anhydroabinosyluracil new transformation
2’-anhydrouracilnucleoside 2
5‘-anhydro-3‘-O-acetyl-2‘
5’-anhydrouracilnucleoside 2
O-triflyluridine 5‘-substituted-2
nucleoside anhydronucleoside 2

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10.1248/cpb.35.4494

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Pankiewicz, K. W., & Watanabe, K. A. (1987). Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)¹⁾. Chemical and Pharmaceutical Bulletin, 35(11), 4494-4497. https://doi.org/10.1248/cpb.35.4494

Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)¹⁾. / Pankiewicz, Krzysztofai W.; Watanabe, Kyoichi A.

In: Chemical and Pharmaceutical Bulletin, Vol. 35, No. 11, 1987, p. 4494-4497.

Research output: Contribution to journal › Article › peer-review

Pankiewicz, KW & Watanabe, KA 1987, 'Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)¹⁾', Chemical and Pharmaceutical Bulletin, vol. 35, no. 11, pp. 4494-4497. https://doi.org/10.1248/cpb.35.4494

Pankiewicz KW, Watanabe KA. Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)¹⁾. Chemical and Pharmaceutical Bulletin. 1987;35(11):4494-4497. doi: 10.1248/cpb.35.4494

Pankiewicz, Krzysztofai W. ; Watanabe, Kyoichi A. / Nucleosides. CXLIII. Synthesis of 5’-Deoxy-5’-substituted-2,2’-anhydro-l-(β-D-arabinofuranosyl)uracils. A New 2,5’- to 2,2’-Anhydro-nucleoside Transformation. Studies Directed toward the Synthesis of 2‘-Deoxy-2’-substituted arabino Nucleosides. (4)¹⁾. In: Chemical and Pharmaceutical Bulletin. 1987 ; Vol. 35, No. 11. pp. 4494-4497.

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