TY - JOUR
T1 - Nucleoside-5'-phosphoimidazolides
T2 - reagents for facile synthesis of dinucleoside pyrophosphates.
AU - Chen, Liqiang
AU - Rejman, Dominik
AU - Bonnac, Laurent
AU - Pankiewicz, Krzysztof W.
AU - Patterson, Steven E.
PY - 2006/1
Y1 - 2006/1
N2 - A facile method is presented for preparation of dinucleoside pyrophosphate derivatives based on reaction of a nucleoside 5'-monophosphate with carbonyldiimidazole followed by treatment of the resulting nucleoside 5'-phosphoimidazolide with a nucleoside 5'-phosphate. This method is suitable for preparation of pyrophosphates analogous to NAD, FAD, and related natural pyrophosphates. The resulting compounds are useful for mechanistic studies of enzymes that use natural pyrophosphates as co-factors or substrates, and in development of inhibitors that have potential applications as therapeutic agents.
AB - A facile method is presented for preparation of dinucleoside pyrophosphate derivatives based on reaction of a nucleoside 5'-monophosphate with carbonyldiimidazole followed by treatment of the resulting nucleoside 5'-phosphoimidazolide with a nucleoside 5'-phosphate. This method is suitable for preparation of pyrophosphates analogous to NAD, FAD, and related natural pyrophosphates. The resulting compounds are useful for mechanistic studies of enzymes that use natural pyrophosphates as co-factors or substrates, and in development of inhibitors that have potential applications as therapeutic agents.
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M3 - Article
C2 - 18428947
AN - SCOPUS:48849106268
SN - 1934-9270
VL - Chapter 13
SP - Unit 13.4
JO - Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
JF - Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]
ER -