Nuclear matrix as an anchor for protein kinase CK2 nuclear signalling

Sherif Tawfic, Russell A. Faust, Markus Gapany, Khalil Ahmed

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Nuclear matrix (NM) is not only the structural basis for nuclear shape but also is intimately involved in nuclear functional activities. Among the modulatory factors that may affect these diverse activities are the signals that may influence the state or composition of the NM proteins. One such mechanism for altering the functional activity of at least some NM proteins may be the extent of their phosphorylation. Protein kinase CK2 appears to associate with NM and to phosphorylate a number of NM-associated proteins. Chromatin- and NM-associated CK2 is rapidly modulated by mitogenic signals. We propose that NM serves as a physiological anchor for nuclear signalling of protein kinase CK2 which may influence functions of NM such as transcription of active genes and growth.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalJournal of Cellular Biochemistry
Volume62
Issue number2
DOIs
StatePublished - Aug 1996

Keywords

  • cell growth
  • chromatin
  • nuclear matrix
  • nuclear translocation
  • phosphorylation
  • prostate
  • protein kinase CK2

Fingerprint Dive into the research topics of 'Nuclear matrix as an anchor for protein kinase CK2 nuclear signalling'. Together they form a unique fingerprint.

Cite this