Novel therapeutic medications for venous thromboembolism prevention in trauma patients: Findings from the Consensus Conference to Implement Optimal Venous Thromboembolism Prophylaxis in Trauma

Navpreet K. Dhillon, Elliott R. Haut, Michelle A. Price, Todd W. Costantini, Amanda L. Teichman, Bryan A. Cotton, Eric J. Ley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Trauma patients are at high risk for venous thromboembolism (VTE). Despite evidence-based guidelines and concerted efforts in trauma centers to implement optimal chemoprophylaxis strategies, VTE remains a frequent diagnosis in trauma patients. Current chemoprophylaxis strategies largely focus on the subcutaneous injection of low-molecular-weight heparin, which is administered twice daily. Novel approaches to pharmacologic VTE prophylaxis have the potential to reduce VTE rates by improving patient compliance through oral administration or through their ability to target alternative pathways that mediate thrombosis. While novel pharmacologic VTE prophylaxis strategies have been studied in nontrauma patients, there is a paucity of literature in trauma patients where the risk of thrombosis versus hemorrhage must be carefully considered. As a component of the 2022 Consensus Conference to Implement Optimal VTE Prophylaxis in Trauma, this review provides an update of the novel chemoprophylaxis agents for potential use in trauma patients. Here, we will consider the relative risks and benefits related to the use of these drugs, evaluate the current literature in nontrauma patients, and consider future directions that could potentially improve posttrauma VTE prophylaxis.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalJournal of Trauma and Acute Care Surgery
Volume94
Issue number3
DOIs
StatePublished - Mar 1 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • Apixaban
  • aspirin
  • low-molecular weight heparin
  • rivaroxaban
  • venous thromboembolism

PubMed: MeSH publication types

  • Review
  • Journal Article
  • Research Support, N.I.H., Extramural

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