Novel therapeutic agents against endotoxemia and septic shock

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Upon bacterial infection, the release of lipopolysaccharide (LPS) endotoxin from Gram-negative bacterial membranes triggers the production of large quantities of cytokines in the body, which can lead to septic shock and eventual death. Various therapeutic strategies have been used to target different stages of the condition, e.g., antibodies against LPS or cytokines, with little success in the clinic. Recently, two approaches have provided hope - the use of anticoagulants and cationic peptide-based agents that bind to and neutralize LPS. Here, we focus the review on recent advances towards the development of therapeutic agents against endotoxemia and septic shock.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalDrugs of the Future
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2008

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