Novel swelling/shrinking behaviors of glucose-binding hydrogels and their potential use in a microfluidic insulin delivery system

Ronald A. Siegel, Yuandong Gu, Antonio Baldi, Babak Ziaie

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Hydrogels based on lightly crosslinked poly(methacrylamidophenylboronic acid-co-acylamide) swell monototically at pH 7.4 with exposure to increasing concentrations of glucose. At pH 10 these hydrogels first shrink and then reswell with increasing glucose concentration. A mechanism for these disctinct behaviors is proposed and preliminary results validating this mechanism are presented. A simple micro fabricated glucose-sensitive valve based on this hydrogel is described.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalMacromolecular Symposia
Volume207
DOIs
StatePublished - Feb 1 2004

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