Novel surfactant peptide for removal of biofilms

Wen Sun, Yibing Wang, Wenxue Zhang, Hanjie Ying, Ping Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Conventional chemical surfactants attach on blots randomly, accompanied with health and environmental issues. To address this, a surfactant peptide was designed to mimic chemical surfactants with an affinity binding peptide as a hydrophobic tail for the cleanup of biofilm contaminations. The micelle forming and structural changes of the peptide in aqueous solution were systematically investigated. More importantly, the biofilm removal efficiency toward Escherichia coli O157:H7 biofilm reached 75% in neutral aqueous solutions at the concentration of 125 mg/L (critical micelle concentration 91 mg/L), a significant improvement in comparison to conventional surfactants and random surfactant peptide. The dynamic removal process reported by confocal laser scanning microscope (CLSM) also displayed the different constituents of biofilm blots, which associated with surfactant peptide binding efficiency. Hopefully, this surfactant strategy will eventually provide new scopes in the design of surface active biological agents.

Original languageEnglish (US)
Pages (from-to)180-186
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
StatePublished - Dec 1 2018

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China ( 31471659 , 21636003 and 21303050 ).

Publisher Copyright:
© 2018 Elsevier B.V.


  • Affinity binding
  • Biofilm
  • Biosurfactant
  • Escherichia coli O157:H7
  • Surfactant peptide


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