Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging

Keyphrases

• Small Molecule Inhibitors 100%
• Healthspan 100%
• Senescence 100%
• NF-B 100%
• Ageing Mouse Model 100%
• Cellular Senescence 60%
• Aging 40%
• Mouse Model 40%
• Oxidative Stress 20%
• Signaling Pathway 20%
• Small Molecules 20%
• Stress-induced 20%
• Etoposide 20%
• Rare Variants 20%
• Therapeutic Effect 20%
• Family Members 20%
• Senescence Cells 20%
• Multiple Parameters 20%
• Mouse Embryonic Fibroblasts 20%
• Chronic Administration 20%
• WT Mice 20%
• Accelerated Aging 20%
• Stem Cell Deficiency 20%
• ERCC1 20%
• Senescent Mouse 20%
• Centenarians 20%
• ZMPSTE24 20%
• IMR-90 20%
• Senescence-associated β-galactosidase 20%
• Two-year-olds 20%
• Muscle Fiber Size 20%
• Promising Target 20%
• Age-related Illnesses 20%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Mouse Model 100%
• Model of Aging 100%
• Stem Cell 33%
• Oxidative Stress 33%
• Wild Type Mouse 33%
• Senescence-Associated Beta-Galactosidase 33%
• Fibroblast 33%
• Rare Variant 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Mouse Model 100%
• Etoposide 33%
• Wild Type Mouse 33%
• Therapeutic Effect 33%
• Beta Galactosidase 33%
• Diseases 33%